TY - JOUR
T1 - Outcome and predictors of failure of highly active antiretroviral therapy
T2 - One-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons
AU - Wit, Ferdinand W.N.M.
AU - Van Leeuwen, Remko
AU - Weverling, Gerrit Jan
AU - Jurriaans, Suzanne
AU - Nauta, Klaas
AU - Steingrover, Radjin
AU - Schuijtemaker, Johan
AU - Eyssen, Xander
AU - Fortuin, David
AU - Weeda, Marjan
AU - De Wolf, Frank
AU - Reiss, Peter
AU - Danner, Sven A.
AU - Lange, Joep M.A.
PY - 1999
Y1 - 1999
N2 - The outcome and predictors of virologic treatment failure of highly active antiretroviral therapy (HAART) were determined for 271 human immunodeficiency virus (HIV)-infected protease inhibitor-naive persons. During a follow-up of 48 weeks after the initiation of HAART, 6.3% of patients experienced at least one new AIDS-defining event, and 3.0% died. Virologic treatment failure occurred in 40% (indinavir, 27%; ritonavir, 30%; saquinavir, 59%; ritonavir plus saquinavir, 32%; χ2, P = .001). Risk factors for treatment failure were baseline plasma HIV-1 RNA (odds ratio [OR], 1.70 per log10 copies increase in plasma HIV-1 RNA), baseline CD4 cell count (OR, 1.35 per 100 CD4 cells/mm3 decrease), and use of saquinavir versus other protease inhibitors (OR, 3.21). During the first year of treatment, 53% of all patients changed (part of) their original HAART regimen at least once. This was significantly more frequent for regimens containing saquinavir (62%; 27% for virologic failure) or ritonavir (64%; 55% for intolerance) as single protease inhibitor.
AB - The outcome and predictors of virologic treatment failure of highly active antiretroviral therapy (HAART) were determined for 271 human immunodeficiency virus (HIV)-infected protease inhibitor-naive persons. During a follow-up of 48 weeks after the initiation of HAART, 6.3% of patients experienced at least one new AIDS-defining event, and 3.0% died. Virologic treatment failure occurred in 40% (indinavir, 27%; ritonavir, 30%; saquinavir, 59%; ritonavir plus saquinavir, 32%; χ2, P = .001). Risk factors for treatment failure were baseline plasma HIV-1 RNA (odds ratio [OR], 1.70 per log10 copies increase in plasma HIV-1 RNA), baseline CD4 cell count (OR, 1.35 per 100 CD4 cells/mm3 decrease), and use of saquinavir versus other protease inhibitors (OR, 3.21). During the first year of treatment, 53% of all patients changed (part of) their original HAART regimen at least once. This was significantly more frequent for regimens containing saquinavir (62%; 27% for virologic failure) or ritonavir (64%; 55% for intolerance) as single protease inhibitor.
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U2 - 10.1086/314675
DO - 10.1086/314675
M3 - Article
C2 - 10068573
AN - SCOPUS:0004674209
SN - 0022-1899
VL - 179
SP - 790
EP - 798
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -