Outcome after temporal lobectomy in bilateral temporal lobe epilepsy

Joseph I. Sirven, Barbara L. Malamut, Joyce D. Liporace, Michael J. O'Connor, Michael R. Sperling

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We determined how noninvasive presurgical data relate to prognosis after temporal lobectomy in patients with independent bilateral temporal lobe (IBTL) complex partial seizures on the intracranial electroencephalogram (EEG). Between 1986 and 1994, 28 patients had IBTL seizures on intracranial EEG. Fifteen of these 28 patients underwent temporal lobectomy and 13 were not offered surgery. Of the 15 patients who had surgery, 10 patients became seizure-free. Magnetic resonance imaging (MRI) and the Wada test were the only variables associated with a seizure-free outcome. Seven of 10 seizure- free patients had a lateralized Wada result or the presence of unilateral hippocampal sclerosis, whereas none of the patients with persistent seizures had either of these findings. Variables not found to be predictive of a seizure-free outcome included location of scalp interictal spikes, degree of seizure-onset laterality, presence of early epilepsy risk factor, duration of epilepsy, and full-scale intelligence quotient. We conclude that MRI and the Wada test provide information of prognostic value in patients with bilateral temporal seizures independent of intracranial EEG data.

Original languageEnglish (US)
Pages (from-to)873-878
Number of pages6
JournalAnnals of Neurology
Volume42
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Seizures
Electroencephalography
Temporal Lobe
Epilepsy
Magnetic Resonance Imaging
Sclerosis
Scalp
Intelligence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sirven, J. I., Malamut, B. L., Liporace, J. D., O'Connor, M. J., & Sperling, M. R. (1997). Outcome after temporal lobectomy in bilateral temporal lobe epilepsy. Annals of Neurology, 42(6), 873-878. https://doi.org/10.1002/ana.410420608

Outcome after temporal lobectomy in bilateral temporal lobe epilepsy. / Sirven, Joseph I.; Malamut, Barbara L.; Liporace, Joyce D.; O'Connor, Michael J.; Sperling, Michael R.

In: Annals of Neurology, Vol. 42, No. 6, 12.1997, p. 873-878.

Research output: Contribution to journalArticle

Sirven, JI, Malamut, BL, Liporace, JD, O'Connor, MJ & Sperling, MR 1997, 'Outcome after temporal lobectomy in bilateral temporal lobe epilepsy', Annals of Neurology, vol. 42, no. 6, pp. 873-878. https://doi.org/10.1002/ana.410420608
Sirven JI, Malamut BL, Liporace JD, O'Connor MJ, Sperling MR. Outcome after temporal lobectomy in bilateral temporal lobe epilepsy. Annals of Neurology. 1997 Dec;42(6):873-878. https://doi.org/10.1002/ana.410420608
Sirven, Joseph I. ; Malamut, Barbara L. ; Liporace, Joyce D. ; O'Connor, Michael J. ; Sperling, Michael R. / Outcome after temporal lobectomy in bilateral temporal lobe epilepsy. In: Annals of Neurology. 1997 ; Vol. 42, No. 6. pp. 873-878.
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