Outcome after surgery for mitral regurgitation. Determinants of postoperative morbidity and mortality

Karl S. Dujardin, James B. Seward, Thomas A. Orszulak, Hartzell V Schaff, Kent R Bailey, A. Jamil Tajik, Maurice E Sarano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and aims of the study: The incidence and impact of congestive heart failure and coronary artery disease on late survival after surgical correction of mitral regurgitation are poorly defined. In addition to the uncertainty about the frequency of this complication, the mechanisms of heart failure have not been fully analyzed. Methods: To determine survival and the incidence and mechanisms of congestive heart failure after mitral valve surgery for mitral regurgitation, we analyzed the long-term outcome of 576 consecutive postoperative survivors. Results: The analysis demonstrated that preserved preoperative left ventricular function (ejection fraction ≤ 60%) was associated with improved survival (adjusted risk ratio 0.49; 95% C.I. 0.36-0.661) and reduced incidence of congestive heart failure (adjusted risk ratio 0.30; 95% C.I. 0.20-0.441), while concomitant coronary artery disease was associated with an excess mortality (adjusted risk ratio 1.80; 95% C.I. 1.34-2.41) and incidence of congestive heart failure (adjusted risk ratio 2.12; 95% C.I. 1.48-3.031). Conclusion: These results suggest that left ventricular dysfunction and coronary artery disease are major determinants of mortality and morbidity after surgical correction of mitral regurgitation. For the prevention of postoperative congestive heart failure, early surgical correction of mitral regurgitation should be considered before left ventricular dysfunction occurs.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Heart Valve Disease
Volume6
Issue number1
StatePublished - Jan 1997

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Mitral Valve Insufficiency
Heart Failure
Morbidity
Mortality
Odds Ratio
Coronary Artery Disease
Left Ventricular Dysfunction
Survival
Incidence
Mitral Valve
Left Ventricular Function
Stroke Volume
Uncertainty
Survivors
Cohort Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Outcome after surgery for mitral regurgitation. Determinants of postoperative morbidity and mortality. / Dujardin, Karl S.; Seward, James B.; Orszulak, Thomas A.; Schaff, Hartzell V; Bailey, Kent R; Tajik, A. Jamil; Sarano, Maurice E.

In: Journal of Heart Valve Disease, Vol. 6, No. 1, 01.1997, p. 17-21.

Research output: Contribution to journalArticle

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AU - Orszulak, Thomas A.

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AU - Bailey, Kent R

AU - Tajik, A. Jamil

AU - Sarano, Maurice E

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