Osteosclerotic myeloma and peripheral neuropathy

J. J. Kelly, R. A. Kyle, J. M. Miles, Peter J Dyck

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215 Citations (Scopus)

Abstract

Sixteen cases of osteosclerotic myeloma and peripheral neuropathy (SM-PN) were reviewed. The neuropathy resembled chronic inflammatory-demyelinating polyneuropathy with predominantly motor disability, high CSF protein levels, and low motor nerve conduction velocities. Twelve of the 16 patients had detectable levels of monoclonal serum proteins, all with λ light chains, but results of other laboratory studies were usually normal. Most of the patients also had organomegaly, endocrine abnormalities, or both. Treatment of solitary lesions with tumoricidal irradiation usually improved the neuropathy and reversed the nonneurologic abnormalities; chemotherapy for multiple osteosclerotic lesions was less helpful.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalNeurology
Volume33
Issue number2
StatePublished - 1983

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Peripheral Nervous System Diseases
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Neural Conduction
Blood Proteins
Light
Drug Therapy
Proteins
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

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Kelly, J. J., Kyle, R. A., Miles, J. M., & Dyck, P. J. (1983). Osteosclerotic myeloma and peripheral neuropathy. Neurology, 33(2), 202-210.

Osteosclerotic myeloma and peripheral neuropathy. / Kelly, J. J.; Kyle, R. A.; Miles, J. M.; Dyck, Peter J.

In: Neurology, Vol. 33, No. 2, 1983, p. 202-210.

Research output: Contribution to journalArticle

Kelly, JJ, Kyle, RA, Miles, JM & Dyck, PJ 1983, 'Osteosclerotic myeloma and peripheral neuropathy', Neurology, vol. 33, no. 2, pp. 202-210.
Kelly JJ, Kyle RA, Miles JM, Dyck PJ. Osteosclerotic myeloma and peripheral neuropathy. Neurology. 1983;33(2):202-210.
Kelly, J. J. ; Kyle, R. A. ; Miles, J. M. ; Dyck, Peter J. / Osteosclerotic myeloma and peripheral neuropathy. In: Neurology. 1983 ; Vol. 33, No. 2. pp. 202-210.
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