Osteosarcoma of the upper extremities: A national analysis of the US population

Maria T. Huayllani, David J. Restrepo, Daniel Boczar, Andrea Sisti, Aaron C. Spaulding, Alexander S. Parker, Rachel Sarabia-Estrada, Hugo Guerrero-Cazares, Steven L. Moran, Antonio J. Forte

Research output: Contribution to journalArticle

Abstract

Background/Aim: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. Materials and Methods: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. Results: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8%), larger than 8 cm (47.9%), high grade (64.3%), lymph node-negative (7.9%), and without metastasis to lungs (39.0%). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. Conclusion: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease.

Original languageEnglish (US)
Pages (from-to)5663-5668
Number of pages6
JournalAnticancer Research
Volume39
Issue number10
DOIs
StatePublished - Jan 1 2019

Fingerprint

Osteosarcoma
Upper Extremity
Population
Logistic Models
Wrist
Amputation
Forearm
Neoplasms
Arm
Cohort Studies
Survival Rate
Retrospective Studies
Hand
Lymph Nodes
Databases
Neoplasm Metastasis
Lung
Survival

Keywords

  • Characteristics
  • NCDB
  • Osteosarcoma
  • Upper extremity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Osteosarcoma of the upper extremities : A national analysis of the US population. / Huayllani, Maria T.; Restrepo, David J.; Boczar, Daniel; Sisti, Andrea; Spaulding, Aaron C.; Parker, Alexander S.; Sarabia-Estrada, Rachel; Guerrero-Cazares, Hugo; Moran, Steven L.; Forte, Antonio J.

In: Anticancer Research, Vol. 39, No. 10, 01.01.2019, p. 5663-5668.

Research output: Contribution to journalArticle

@article{9fded29a5e224c1f8b9eb386bc3e04a1,
title = "Osteosarcoma of the upper extremities: A national analysis of the US population",
abstract = "Background/Aim: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. Materials and Methods: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. Results: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8{\%}), larger than 8 cm (47.9{\%}), high grade (64.3{\%}), lymph node-negative (7.9{\%}), and without metastasis to lungs (39.0{\%}). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. Conclusion: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease.",
keywords = "Characteristics, NCDB, Osteosarcoma, Upper extremity",
author = "Huayllani, {Maria T.} and Restrepo, {David J.} and Daniel Boczar and Andrea Sisti and Spaulding, {Aaron C.} and Parker, {Alexander S.} and Rachel Sarabia-Estrada and Hugo Guerrero-Cazares and Moran, {Steven L.} and Forte, {Antonio J.}",
year = "2019",
month = "1",
day = "1",
doi = "10.21873/anticanres.13763",
language = "English (US)",
volume = "39",
pages = "5663--5668",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "10",

}

TY - JOUR

T1 - Osteosarcoma of the upper extremities

T2 - A national analysis of the US population

AU - Huayllani, Maria T.

AU - Restrepo, David J.

AU - Boczar, Daniel

AU - Sisti, Andrea

AU - Spaulding, Aaron C.

AU - Parker, Alexander S.

AU - Sarabia-Estrada, Rachel

AU - Guerrero-Cazares, Hugo

AU - Moran, Steven L.

AU - Forte, Antonio J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/Aim: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. Materials and Methods: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. Results: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8%), larger than 8 cm (47.9%), high grade (64.3%), lymph node-negative (7.9%), and without metastasis to lungs (39.0%). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. Conclusion: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease.

AB - Background/Aim: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. Materials and Methods: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. Results: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8%), larger than 8 cm (47.9%), high grade (64.3%), lymph node-negative (7.9%), and without metastasis to lungs (39.0%). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. Conclusion: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease.

KW - Characteristics

KW - NCDB

KW - Osteosarcoma

KW - Upper extremity

UR - http://www.scopus.com/inward/record.url?scp=85072785509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072785509&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13763

DO - 10.21873/anticanres.13763

M3 - Article

C2 - 31570464

AN - SCOPUS:85072785509

VL - 39

SP - 5663

EP - 5668

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 10

ER -