Osteosarcoma - an evaluation of current diagnosis, treatment and chemotherapy

Bahtiyar Demiralp; Gobinda Sarkar; Scott H. Okuno; Michael J. Yaszemski; Avudaiappan Maran

Osteosarcoma - an evaluation of current diagnosis, treatment and chemotherapy

Bahtiyar Demiralp, Gobinda Sarkar, Scott H. Okuno, Michael J. Yaszemski, Avudaiappan Maran

Research output: Contribution to journal › Article › peer-review

Abstract

Osteosarcoma is a bone tumour that most often affects children and young adults. Although a combination of surgery to remove the primary tumour and chemotherapy prior to and after the surgery has led to an improved survival rate, local recurrence and metastases still develop in two-fifths of patients. A definitive therapy is yet to be determined for this deadly disease. This article discusses the current status on diagnosis and treatment, with an emphasis on developing new molecularly targeted therapies.

Original language	English (US)
Pages (from-to)	18-23
Number of pages	6
Journal	European Musculoskeletal Review
Volume	6
Issue number	1
State	Published - Feb 1 2011

Keywords

2-methoxyestradiol
Bone tumour
Chemotherapy
Osteosarcoma
Sarcoma
Tumour surgery

ASJC Scopus subject areas

Orthopedics and Sports Medicine

Cite this

@article{17d1aee110ee4278944f2b48ab048c72,

title = "Osteosarcoma - an evaluation of current diagnosis, treatment and chemotherapy",

abstract = "Osteosarcoma is a bone tumour that most often affects children and young adults. Although a combination of surgery to remove the primary tumour and chemotherapy prior to and after the surgery has led to an improved survival rate, local recurrence and metastases still develop in two-fifths of patients. A definitive therapy is yet to be determined for this deadly disease. This article discusses the current status on diagnosis and treatment, with an emphasis on developing new molecularly targeted therapies.",

keywords = "2-methoxyestradiol, Bone tumour, Chemotherapy, Osteosarcoma, Sarcoma, Tumour surgery",

author = "Bahtiyar Demiralp and Gobinda Sarkar and Okuno, {Scott H.} and Yaszemski, {Michael J.} and Avudaiappan Maran",

year = "2011",

month = feb,

day = "1",

language = "English (US)",

volume = "6",

pages = "18--23",

journal = "European Musculoskeletal Review",

issn = "1754-5072",

publisher = "Touch Briefings",

number = "1",

}

TY - JOUR

T1 - Osteosarcoma - an evaluation of current diagnosis, treatment and chemotherapy

AU - Demiralp, Bahtiyar

AU - Sarkar, Gobinda

AU - Okuno, Scott H.

AU - Yaszemski, Michael J.

AU - Maran, Avudaiappan

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Osteosarcoma is a bone tumour that most often affects children and young adults. Although a combination of surgery to remove the primary tumour and chemotherapy prior to and after the surgery has led to an improved survival rate, local recurrence and metastases still develop in two-fifths of patients. A definitive therapy is yet to be determined for this deadly disease. This article discusses the current status on diagnosis and treatment, with an emphasis on developing new molecularly targeted therapies.

AB - Osteosarcoma is a bone tumour that most often affects children and young adults. Although a combination of surgery to remove the primary tumour and chemotherapy prior to and after the surgery has led to an improved survival rate, local recurrence and metastases still develop in two-fifths of patients. A definitive therapy is yet to be determined for this deadly disease. This article discusses the current status on diagnosis and treatment, with an emphasis on developing new molecularly targeted therapies.

KW - 2-methoxyestradiol

KW - Bone tumour

KW - Chemotherapy

KW - Osteosarcoma

KW - Sarcoma

KW - Tumour surgery

UR - http://www.scopus.com/inward/record.url?scp=79954615808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954615808&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79954615808

SN - 1754-5072

VL - 6

SP - 18

EP - 23

JO - European Musculoskeletal Review

JF - European Musculoskeletal Review

IS - 1

ER -

Osteosarcoma - an evaluation of current diagnosis, treatment and chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this