Osteoporosis of Crohn's disease: A critical review

Neena S. Abraham, Richard N. Fedorak

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Osteoporosis has long been a recognized complication of Crohn's disease (CD), with a documented incidence ranging from 31% to 65%. The cause of osteoporosis in Crohn's patients is likely multifactorial; corticosteroids, inflammatory cytokines, small bowel resection and the resultant calcium and vitamin D deficiencies, hypogonadism, malnutrition and the cachexia of inflammation all play a role. However, the mechanism responsible for osteoporosis associated with CD remains unclear. Treatment of decreased bone density in CD patients has been limited to calcium and vitamin D replacement. The present understanding of the pathophysiology, mechanism and treatment of osteoporosis in CD is reviewed, with the focus on the role of steroid-induced osteoporosis and the use of bisphosphonates.

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalCanadian Journal of Gastroenterology
Volume10
Issue number5
DOIs
StatePublished - Sep 1996

Keywords

  • Bisphosphonate
  • Crohn's disease
  • Inflammatory bowel disease
  • Osteoporosis

ASJC Scopus subject areas

  • Gastroenterology

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