Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings

Vladimir Egorov, Alexey Tatarinov, Noune Sarvazyan, Randee Wood, Leonid Magidenko, Shreyasee Amin, Sundeep Khosla, Richard J. Ruh, Jennifer M. Ruh, Armen Sarvazyan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the "gold standard" for the assessment of osteoporosis (T-score <-2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS's capability to detect osteoporosis in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1170-1177
Number of pages8
JournalUltrasonics
Volume54
Issue number5
DOIs
StatePublished - 2014

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ultrasonic scanners
osteoporosis
bones
curves
tibia
spine
classifiers
wave propagation
acquisition
receivers
operators
output
sensitivity
profiles

Keywords

  • Axial scanning
  • Bone quantitative ultrasound
  • Multi-frequency
  • Osteoporosis
  • Wave propagation parameters

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer : Clinical findings. / Egorov, Vladimir; Tatarinov, Alexey; Sarvazyan, Noune; Wood, Randee; Magidenko, Leonid; Amin, Shreyasee; Khosla, Sundeep; Ruh, Richard J.; Ruh, Jennifer M.; Sarvazyan, Armen.

In: Ultrasonics, Vol. 54, No. 5, 2014, p. 1170-1177.

Research output: Contribution to journalArticle

Egorov, V, Tatarinov, A, Sarvazyan, N, Wood, R, Magidenko, L, Amin, S, Khosla, S, Ruh, RJ, Ruh, JM & Sarvazyan, A 2014, 'Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings', Ultrasonics, vol. 54, no. 5, pp. 1170-1177. https://doi.org/10.1016/j.ultras.2013.08.017
Egorov, Vladimir ; Tatarinov, Alexey ; Sarvazyan, Noune ; Wood, Randee ; Magidenko, Leonid ; Amin, Shreyasee ; Khosla, Sundeep ; Ruh, Richard J. ; Ruh, Jennifer M. ; Sarvazyan, Armen. / Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer : Clinical findings. In: Ultrasonics. 2014 ; Vol. 54, No. 5. pp. 1170-1177.
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