Abstract
The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the "gold standard" for the assessment of osteoporosis (T-score <-2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS's capability to detect osteoporosis in postmenopausal women.
Original language | English (US) |
---|---|
Pages (from-to) | 1170-1177 |
Number of pages | 8 |
Journal | Ultrasonics |
Volume | 54 |
Issue number | 5 |
DOIs | |
State | Published - Jul 2014 |
Keywords
- Axial scanning
- Bone quantitative ultrasound
- Multi-frequency
- Osteoporosis
- Wave propagation parameters
ASJC Scopus subject areas
- Acoustics and Ultrasonics