Osteocalcin and the regulation of glucose metabolism

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Uncarboxylated osteocalcin enhances insulin and adiponectin release and improves glucose tolerance in mice. Data in humans do not unequivocally support a role for osteocalcin in glucose homeostasis. Changes in the amount of uncarboxylated osteocalcin induced by vitamin K or warfarin treatment are not associated with changes in glucose and insulin concentrations. Interventional studies in humans, designed to detect small changes in insulin secretion and action attributable to changes in uncarboxylated osteocalcin, will be required to reliably detect effects of osteocalcin on glucose metabolism and to better understand its interaction with adiposity and adipokines.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalClinical Reviews in Bone and Mineral Metabolism
Volume11
Issue number1
DOIs
StatePublished - Mar 2013

Keywords

  • Adiponectin
  • Glucose
  • Insulin
  • Osteocalcin
  • Undercarboxylated osteocalcin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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