Osteocalcin and the regulation of glucose metabolism

Adrian Vella; Rajiv Kumar

doi:10.1007/s12018-012-9126-x

Osteocalcin and the regulation of glucose metabolism

Adrian Vella, Rajiv Kumar

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Uncarboxylated osteocalcin enhances insulin and adiponectin release and improves glucose tolerance in mice. Data in humans do not unequivocally support a role for osteocalcin in glucose homeostasis. Changes in the amount of uncarboxylated osteocalcin induced by vitamin K or warfarin treatment are not associated with changes in glucose and insulin concentrations. Interventional studies in humans, designed to detect small changes in insulin secretion and action attributable to changes in uncarboxylated osteocalcin, will be required to reliably detect effects of osteocalcin on glucose metabolism and to better understand its interaction with adiposity and adipokines.

Original language	English (US)
Pages (from-to)	11-16
Number of pages	6
Journal	Clinical Reviews in Bone and Mineral Metabolism
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s12018-012-9126-x
State	Published - Mar 2013

Keywords

Adiponectin
Glucose
Insulin
Osteocalcin
Undercarboxylated osteocalcin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

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10.1007/s12018-012-9126-x

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abstract = "Uncarboxylated osteocalcin enhances insulin and adiponectin release and improves glucose tolerance in mice. Data in humans do not unequivocally support a role for osteocalcin in glucose homeostasis. Changes in the amount of uncarboxylated osteocalcin induced by vitamin K or warfarin treatment are not associated with changes in glucose and insulin concentrations. Interventional studies in humans, designed to detect small changes in insulin secretion and action attributable to changes in uncarboxylated osteocalcin, will be required to reliably detect effects of osteocalcin on glucose metabolism and to better understand its interaction with adiposity and adipokines.",

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author = "Adrian Vella and Rajiv Kumar",

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AB - Uncarboxylated osteocalcin enhances insulin and adiponectin release and improves glucose tolerance in mice. Data in humans do not unequivocally support a role for osteocalcin in glucose homeostasis. Changes in the amount of uncarboxylated osteocalcin induced by vitamin K or warfarin treatment are not associated with changes in glucose and insulin concentrations. Interventional studies in humans, designed to detect small changes in insulin secretion and action attributable to changes in uncarboxylated osteocalcin, will be required to reliably detect effects of osteocalcin on glucose metabolism and to better understand its interaction with adiposity and adipokines.

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Osteocalcin and the regulation of glucose metabolism

Abstract

Keywords

ASJC Scopus subject areas

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