Osteoblast adhesion on biodegradable polymer substrates

Susan L. Ishaug, Michael J Yaszemski, Rena Bizios, Antonios G. Mikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have investigated the adhesion of rat osteoblast on biodegradable poly(α-hydroxy ester) films as an in vitro model of bone regeneration. Osteoblasts cultured on poly(L-lactic acid), poly(DL-lactic-co-glycolic acid) copolymer, and poly(glycolic acid) films for 14 days grew with rates comparable to those observed for tissue culture polystyrene and retained their phenotype as expressed by activity of alkaline phosphatase and collagen synthesis.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
Place of PublicationPittsburgh, PA, United States
PublisherPubl by Materials Research Society
Pages121-126
Number of pages6
Volume331
ISBN (Print)1558992308
StatePublished - 1994
Externally publishedYes
EventProceedings of the Biomaterials for Drug and Cell Delivery - Boston, MA, USA
Duration: Nov 29 1993Dec 1 1993

Other

OtherProceedings of the Biomaterials for Drug and Cell Delivery
CityBoston, MA, USA
Period11/29/9312/1/93

Fingerprint

Biodegradable polymers
glycolic acid
Osteoblasts
adhesion
Adhesion
polymer
substrate
Tissue culture
Acids
acid
Polystyrenes
Phosphatases
Substrates
Lactic acid
Collagen
Alkaline Phosphatase
Rats
Esters
Bone
Copolymers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Engineering(all)
  • Earth and Planetary Sciences(all)
  • Environmental Science(all)

Cite this

Ishaug, S. L., Yaszemski, M. J., Bizios, R., & Mikos, A. G. (1994). Osteoblast adhesion on biodegradable polymer substrates. In Materials Research Society Symposium Proceedings (Vol. 331, pp. 121-126). Pittsburgh, PA, United States: Publ by Materials Research Society.

Osteoblast adhesion on biodegradable polymer substrates. / Ishaug, Susan L.; Yaszemski, Michael J; Bizios, Rena; Mikos, Antonios G.

Materials Research Society Symposium Proceedings. Vol. 331 Pittsburgh, PA, United States : Publ by Materials Research Society, 1994. p. 121-126.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ishaug, SL, Yaszemski, MJ, Bizios, R & Mikos, AG 1994, Osteoblast adhesion on biodegradable polymer substrates. in Materials Research Society Symposium Proceedings. vol. 331, Publ by Materials Research Society, Pittsburgh, PA, United States, pp. 121-126, Proceedings of the Biomaterials for Drug and Cell Delivery, Boston, MA, USA, 11/29/93.
Ishaug SL, Yaszemski MJ, Bizios R, Mikos AG. Osteoblast adhesion on biodegradable polymer substrates. In Materials Research Society Symposium Proceedings. Vol. 331. Pittsburgh, PA, United States: Publ by Materials Research Society. 1994. p. 121-126
Ishaug, Susan L. ; Yaszemski, Michael J ; Bizios, Rena ; Mikos, Antonios G. / Osteoblast adhesion on biodegradable polymer substrates. Materials Research Society Symposium Proceedings. Vol. 331 Pittsburgh, PA, United States : Publ by Materials Research Society, 1994. pp. 121-126
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