Osseous metastases: Drugs that enhance bone integrity and prevent adverse skeletal events

James M. Heun, Aminah Jatoi

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

More than 400,000 cancer patients in the USA contend with bone metastases on an annual basis. These patients often suffer pain, a decline in quality of life, and a shortened survival. As a result, over the past several years, efforts to enhance bone integrity in patients with osseus metastases have become a major research priority. This review discusses the evolving role of bisphosphonates and their side effects, highlights other pharmacological interventions aimed at enhancing bone integrity, and reviews other pragmatic approaches to prevent worsening pain and fractures, as derived from a single institution case series of patients with problematic rib metastases.

Original languageEnglish (US)
Pages (from-to)723-726
Number of pages4
JournalExpert Opinion on Pharmacotherapy
Volume10
Issue number5
DOIs
StatePublished - Apr 1 2009

Keywords

  • Adverse skeletal events
  • Bisphosphonates
  • Bone pain
  • Fracture
  • Osseous metastases
  • Rib

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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