Osseous metastases: Drugs that enhance bone integrity and prevent adverse skeletal events

James M. Heun; Aminah Jatoi

doi:10.1517/14656560902832684

Osseous metastases: Drugs that enhance bone integrity and prevent adverse skeletal events

James M. Heun, Aminah Jatoi

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

More than 400,000 cancer patients in the USA contend with bone metastases on an annual basis. These patients often suffer pain, a decline in quality of life, and a shortened survival. As a result, over the past several years, efforts to enhance bone integrity in patients with osseus metastases have become a major research priority. This review discusses the evolving role of bisphosphonates and their side effects, highlights other pharmacological interventions aimed at enhancing bone integrity, and reviews other pragmatic approaches to prevent worsening pain and fractures, as derived from a single institution case series of patients with problematic rib metastases.

Original language	English (US)
Pages (from-to)	723-726
Number of pages	4
Journal	Expert Opinion on Pharmacotherapy
Volume	10
Issue number	5
DOIs	https://doi.org/10.1517/14656560902832684
State	Published - Apr 2009

Keywords

Adverse skeletal events
Bisphosphonates
Bone pain
Fracture
Osseous metastases
Rib

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Osseous metastases: Drugs that enhance bone integrity and prevent adverse skeletal events",

abstract = "More than 400,000 cancer patients in the USA contend with bone metastases on an annual basis. These patients often suffer pain, a decline in quality of life, and a shortened survival. As a result, over the past several years, efforts to enhance bone integrity in patients with osseus metastases have become a major research priority. This review discusses the evolving role of bisphosphonates and their side effects, highlights other pharmacological interventions aimed at enhancing bone integrity, and reviews other pragmatic approaches to prevent worsening pain and fractures, as derived from a single institution case series of patients with problematic rib metastases.",

keywords = "Adverse skeletal events, Bisphosphonates, Bone pain, Fracture, Osseous metastases, Rib",

author = "Heun, {James M.} and Aminah Jatoi",

note = "Funding Information: This work was funded by K24CA131099. The authors declare no conflict of interest.",

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T2 - Drugs that enhance bone integrity and prevent adverse skeletal events

AU - Heun, James M.

AU - Jatoi, Aminah

N1 - Funding Information: This work was funded by K24CA131099. The authors declare no conflict of interest.

PY - 2009/4

Y1 - 2009/4

N2 - More than 400,000 cancer patients in the USA contend with bone metastases on an annual basis. These patients often suffer pain, a decline in quality of life, and a shortened survival. As a result, over the past several years, efforts to enhance bone integrity in patients with osseus metastases have become a major research priority. This review discusses the evolving role of bisphosphonates and their side effects, highlights other pharmacological interventions aimed at enhancing bone integrity, and reviews other pragmatic approaches to prevent worsening pain and fractures, as derived from a single institution case series of patients with problematic rib metastases.

AB - More than 400,000 cancer patients in the USA contend with bone metastases on an annual basis. These patients often suffer pain, a decline in quality of life, and a shortened survival. As a result, over the past several years, efforts to enhance bone integrity in patients with osseus metastases have become a major research priority. This review discusses the evolving role of bisphosphonates and their side effects, highlights other pharmacological interventions aimed at enhancing bone integrity, and reviews other pragmatic approaches to prevent worsening pain and fractures, as derived from a single institution case series of patients with problematic rib metastases.

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KW - Bone pain

KW - Fracture

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Osseous metastases: Drugs that enhance bone integrity and prevent adverse skeletal events

Abstract

Keywords

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