Orthotopic VX rabbit tongue cancer model with FDG-PET and histologic characterization

Brendan C. Stack, John Ye, Twyla B. Bartel, Gal Shafirstein, Chien Chen, Eric Siegel, Bipin Singh, Samta Thacker, Val J. Lowe, Vivek Nagarkar

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background We present our experience with the use of an immunocompetent medium-sized animal model of tongue cancer that may be suitable for imaging and surgical studies. Methods A New Zealand white rabbit model of tongue cancer was created by injecting a VX tumor cell suspension grown in culture into the tongue of our model. The tumor was examined 7 days following implantation by physical examination, photography, and 18fluoro 2-deoxyglucose-positron emission tomography (FDG-PET). At 12 days postimplantation, the model was again studied as described above prior to euthanization, and then tongue excision and bilateral neck dissections were performed. All tissue was examined by histology. Results We confirmed a successful orthotopic tongue cancer model that resulted in cervical nodal metastases. Conclusion This model may be a useful model of orthotopic head and neck cancer for future surgical or imaging research.

Original languageEnglish (US)
Pages (from-to)1119-1123
Number of pages5
JournalHead and Neck
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • FDG-PET
  • VX
  • head and neck cancer animal model
  • orthotopic

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Stack, B. C., Ye, J., Bartel, T. B., Shafirstein, G., Chen, C., Siegel, E., Singh, B., Thacker, S., Lowe, V. J., & Nagarkar, V. (2013). Orthotopic VX rabbit tongue cancer model with FDG-PET and histologic characterization. Head and Neck, 35(8), 1119-1123. https://doi.org/10.1002/hed.23105