Orthotopic liver transplantation in hepatocellular carcinoma: Comparison of results in incidental and known hepatocellular carcinoma

Taqi F Toufeeq Khan, Kunam Sudhakar Reddy, Thomas D. Johnston, Dinesh Ranjan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Liver transplantation (LTx) is known therapy for hepatocellular carcinoma (HCC). We undertook a retrospective chart review and analysis of our experience with 19 patients with HCC who had undergone LTx between June 1995 and January 2003. We compared the results of 12 patients with known HCC (group I) with that of 7 patients with incidental HCC (group II). We found that the incidence of multifocal disease, lymphatic involvement, and tumor-free survival was not significantly different between the two groups. One patient in group I died of tumor. Patient survival was better in group II (100%), with a median follow-up of 45 months, as 4 more patients in group I (with known HCC) died of reasons unrelated to tumors, with a median follow-up of 23 months. We conclude that LTx in patients with either incidental or known HCC results in excellent tumor-free survival.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalInternational Surgery
Volume91
Issue number4
StatePublished - 2006
Externally publishedYes

Fingerprint

Liver Transplantation
Hepatocellular Carcinoma
Survival
Neoplasms
Lymphatic Diseases
Incidence

Keywords

  • Cirrhosis
  • Hepatocellular carcinoma
  • Incidental
  • Liver transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Orthotopic liver transplantation in hepatocellular carcinoma : Comparison of results in incidental and known hepatocellular carcinoma. / Khan, Taqi F Toufeeq; Reddy, Kunam Sudhakar; Johnston, Thomas D.; Ranjan, Dinesh.

In: International Surgery, Vol. 91, No. 4, 2006, p. 185-187.

Research output: Contribution to journalArticle

@article{29803173e1f84899af0b7b0952c36df3,
title = "Orthotopic liver transplantation in hepatocellular carcinoma: Comparison of results in incidental and known hepatocellular carcinoma",
abstract = "Liver transplantation (LTx) is known therapy for hepatocellular carcinoma (HCC). We undertook a retrospective chart review and analysis of our experience with 19 patients with HCC who had undergone LTx between June 1995 and January 2003. We compared the results of 12 patients with known HCC (group I) with that of 7 patients with incidental HCC (group II). We found that the incidence of multifocal disease, lymphatic involvement, and tumor-free survival was not significantly different between the two groups. One patient in group I died of tumor. Patient survival was better in group II (100{\%}), with a median follow-up of 45 months, as 4 more patients in group I (with known HCC) died of reasons unrelated to tumors, with a median follow-up of 23 months. We conclude that LTx in patients with either incidental or known HCC results in excellent tumor-free survival.",
keywords = "Cirrhosis, Hepatocellular carcinoma, Incidental, Liver transplantation",
author = "Khan, {Taqi F Toufeeq} and Reddy, {Kunam Sudhakar} and Johnston, {Thomas D.} and Dinesh Ranjan",
year = "2006",
language = "English (US)",
volume = "91",
pages = "185--187",
journal = "International Surgery",
issn = "0020-8868",
publisher = "International College of Surgeons",
number = "4",

}

TY - JOUR

T1 - Orthotopic liver transplantation in hepatocellular carcinoma

T2 - Comparison of results in incidental and known hepatocellular carcinoma

AU - Khan, Taqi F Toufeeq

AU - Reddy, Kunam Sudhakar

AU - Johnston, Thomas D.

AU - Ranjan, Dinesh

PY - 2006

Y1 - 2006

N2 - Liver transplantation (LTx) is known therapy for hepatocellular carcinoma (HCC). We undertook a retrospective chart review and analysis of our experience with 19 patients with HCC who had undergone LTx between June 1995 and January 2003. We compared the results of 12 patients with known HCC (group I) with that of 7 patients with incidental HCC (group II). We found that the incidence of multifocal disease, lymphatic involvement, and tumor-free survival was not significantly different between the two groups. One patient in group I died of tumor. Patient survival was better in group II (100%), with a median follow-up of 45 months, as 4 more patients in group I (with known HCC) died of reasons unrelated to tumors, with a median follow-up of 23 months. We conclude that LTx in patients with either incidental or known HCC results in excellent tumor-free survival.

AB - Liver transplantation (LTx) is known therapy for hepatocellular carcinoma (HCC). We undertook a retrospective chart review and analysis of our experience with 19 patients with HCC who had undergone LTx between June 1995 and January 2003. We compared the results of 12 patients with known HCC (group I) with that of 7 patients with incidental HCC (group II). We found that the incidence of multifocal disease, lymphatic involvement, and tumor-free survival was not significantly different between the two groups. One patient in group I died of tumor. Patient survival was better in group II (100%), with a median follow-up of 45 months, as 4 more patients in group I (with known HCC) died of reasons unrelated to tumors, with a median follow-up of 23 months. We conclude that LTx in patients with either incidental or known HCC results in excellent tumor-free survival.

KW - Cirrhosis

KW - Hepatocellular carcinoma

KW - Incidental

KW - Liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=33845717518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845717518&partnerID=8YFLogxK

M3 - Article

C2 - 16967677

AN - SCOPUS:33845717518

VL - 91

SP - 185

EP - 187

JO - International Surgery

JF - International Surgery

SN - 0020-8868

IS - 4

ER -