TY - JOUR
T1 - Origin of the distinction between alzheimer’s disease and senile dementia
T2 - How history can clarify nosology
AU - Amaducci, Luigi A.
AU - Rocca, Walter A.
AU - Schoenberg, Bruce S.
PY - 1986/11
Y1 - 1986/11
N2 - Since the beginning of the century, psychiatrists and neurologists have been arguing about the identity of presenile (Alzheimer’s disease) and senile dementia. History reveals that the distinction was originally based on anecdotal clinical observations and that competition among universities was one of the underlying determinants. The personal opinion of Kraepelin played a major role. Given his widespread reputation and authority, he generated a dogma difficult to change. Reports based on large clinicopathologic series have shown that the pathologies of presenile and senile dementia are not qualitatively different. Although the controversy continues, many have come to regard Alzheimer’s disease and senile dementia as part of the same spectrum of disease, independent of the age of onset.
AB - Since the beginning of the century, psychiatrists and neurologists have been arguing about the identity of presenile (Alzheimer’s disease) and senile dementia. History reveals that the distinction was originally based on anecdotal clinical observations and that competition among universities was one of the underlying determinants. The personal opinion of Kraepelin played a major role. Given his widespread reputation and authority, he generated a dogma difficult to change. Reports based on large clinicopathologic series have shown that the pathologies of presenile and senile dementia are not qualitatively different. Although the controversy continues, many have come to regard Alzheimer’s disease and senile dementia as part of the same spectrum of disease, independent of the age of onset.
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U2 - 10.1212/wnl.36.11.1497
DO - 10.1212/wnl.36.11.1497
M3 - Article
C2 - 3531918
AN - SCOPUS:0023001374
SN - 0028-3878
VL - 36
SP - 1497
EP - 1499
JO - Neurology
JF - Neurology
IS - 11
ER -