Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: Implications for biological control in cancer

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.

Original languageEnglish (US)
Title of host publicationSteroid Enzymes and Cancer
PublisherBlackwell Publishing Inc.
Pages4-14
Number of pages11
ISBN (Print)9781573317450
DOIs
StatePublished - Feb 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1155
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Chromatin
  • Epigenetic control
  • Genomics
  • Nuclear matrix
  • Nuclear microenvironments
  • Proteomics
  • Runx
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Stein, G. S., Zaidi, S. K., Stein, J. L., Lian, J. B., Van Wijnen, A. J., Montecino, M., Young, D. W., Javed, A., Pratap, J., Choi, J. Y., Ali, S. A., Pande, S., & Hassan, M. Q. (2009). Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: Implications for biological control in cancer. In Steroid Enzymes and Cancer (pp. 4-14). (Annals of the New York Academy of Sciences; Vol. 1155). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.03697.x