Organ allocation for chronic liver disease

Model for end-stage liver disease and beyond

Sumeet K. Asrani, W. Ray Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose of Review: Implementation of the model for end-stage liver disease (MELD) score has led to a reduction in waiting list registration and waitlist mortality. Prognostic models have been proposed to either refine or improve the current MELD-based liver allocation. Recent Findings: The model for end-stage liver disease - sodium (MELDNa) incorporates serum sodium and has been shown to improve the predictive accuracy of the MELD score. However, laboratory variation and manipulation of serum sodium is a concern. Organ allocation in the United Kingdom is now based on a model that includes serum sodium. An updated MELD score is associated with a lower relative weight for serum creatinine coefficient and a higher relative weight for bilirubin coefficient, although the contribution of reweighting coefficients as compared with addition of variables is unclear. The D-MELD, the arithmetic product of donor age and preoperative MELD, proposes donor-recipient matching; however, inappropriate transplantation of high-risk donors is a concern. Finally, the net benefit model ranks patients according to the net survival benefit that they would derive from the transplant. However, complex statistical models are required and unmeasured characteristics may unduly affect the model. Summary: Despite their limitations, efforts to improve the current MELD-based organ allocation are encouraging.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalCurrent Opinion in Gastroenterology
Volume26
Issue number3
DOIs
StatePublished - May 2010

Fingerprint

End Stage Liver Disease
Liver Diseases
Chronic Disease
Sodium
Tissue Donors
Serum
Weights and Measures
Waiting Lists
Statistical Models
Bilirubin
Creatinine
Transplantation
Transplants
Survival
Mortality
Liver

Keywords

  • Model for end-stage liver disease - Sodium
  • Organ allocation
  • Product of donor age and model for end-stage liver disease
  • Serum sodium
  • Transplant benefit

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Organ allocation for chronic liver disease : Model for end-stage liver disease and beyond. / Asrani, Sumeet K.; Kim, W. Ray.

In: Current Opinion in Gastroenterology, Vol. 26, No. 3, 05.2010, p. 209-213.

Research output: Contribution to journalArticle

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