Oral steroid therapy in chronic rhinosinusitis with and without nasal polyposis

Brittany E. Howard, Devyani Lal

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous group of disorders characterized by inflammation of the sinonasal mucosa. CRS can be divided into two subtypes: CRS without polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Corticosteroids are frequently employed to treat CRS due to their potent anti-inflammatory effects. Treatment of CRS with oral steroids must be carefully balanced against potential adverse effects. This article reviews the current literature on management of CRS with systemic corticosteroids. We discuss the available evidence in CRSsNP, CRSwNP, and allergic fungal sinusitis (AFS). Studies are evaluated for level of evidence and graded to provide evidence-based recommendations. Our review finds a lack of high-quality evidence supporting oral corticosteroid therapy in CRSsNP. In comparison, randomized controlled trails support the use of oral corticosteroids for CRSwNP. Similarly, systemic steroids for AFS treatment are supported by quality studies demonstrating efficacy. Utilization of steroids is also recommended in the perioperative setting for CRSwNP.

Original languageEnglish (US)
Pages (from-to)236-243
Number of pages8
JournalCurrent Allergy and Asthma Reports
Volume13
Issue number2
DOIs
StatePublished - Apr 1 2013

Keywords

  • Allergic fungal sinusitis
  • Chronic rhinosinusitis
  • Corticosteroids
  • Evidence-based medicine
  • Management
  • Nasal polyps
  • Oral steroid therapy
  • Perioperative
  • Postoperative
  • Preoperative
  • Recommendations
  • Review
  • Sinusitis
  • Steroids

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Oral steroid therapy in chronic rhinosinusitis with and without nasal polyposis'. Together they form a unique fingerprint.

Cite this