Oral Signs of Vesiculobullous and Autoimmune Disease

This chapter is focused on the oral manifestations of vesiculobullous and autoimmune diseases. These diseases often share similar oral presentations with subtle differences. Therefore, eliciting a detailed medical history and a thorough oral examination are necessary, while supporting tests including serologies, biopsies, as well as direct and indirect immunofluorescence are often valuable. Examination of cutaneous skin and non-oral mucosa may offer additional diagnostic and prognostic insights. Oral vesiculobullous and autoimmune diseases can lead to debilitating morbidities such as pain and poor oral intake. These diseases may also serve as windows to internal diseases such as infection and malignancy, which necessitates multidisciplinary care. This chapter describes the epidemiology, etiopathogenesis, clinical manifestations, differential diagnosis, and treatments of oral vesiculobullous and autoimmune diseases, with an emphasis on their oral signs and symptoms.