Oral contrast enhances the resolution of in-life NIS reporter gene imaging

L. Suksanpaisan; L. Pham; S. McIvor; S. J. Russell; K. W. Peng

doi:10.1038/cgt.2013.57

Oral contrast enhances the resolution of in-life NIS reporter gene imaging

L. Suksanpaisan, L. Pham, S. McIvor, S. J. Russell, K. W. Peng

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

Original language	English (US)
Pages (from-to)	638-641
Number of pages	4
Journal	Cancer Gene Therapy
Volume	20
Issue number	11
DOIs	https://doi.org/10.1038/cgt.2013.57
State	Published - Nov 2013

Keywords

NIS
barium sulfate
oral contrast
perigastric
reporter gene

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cancer Research

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10.1038/cgt.2013.57

Cite this

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title = "Oral contrast enhances the resolution of in-life NIS reporter gene imaging",

abstract = "Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.",

keywords = "NIS, barium sulfate, oral contrast, perigastric, reporter gene",

author = "L. Suksanpaisan and L. Pham and S. McIvor and Russell, {S. J.} and Peng, {K. W.}",

note = "Funding Information: We thank Suzanne Greiner (Mayo Clinic) for her veterinary expertise, Michael K O{\textquoteright}Connor (Radiology, Mayo Clinic) for critical review of the manuscript, Tracy Decklever and Brad Kemp (Radiology, Mayo Clinic) of the Mayo Clinic Small Animal Imaging Core. This work was supported by the Mayo Foundation and grants from the National Institutes of Health (R01CA129193, R01CA100634, R01CA129966).",

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doi = "10.1038/cgt.2013.57",

language = "English (US)",

volume = "20",

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AU - Pham, L.

AU - McIvor, S.

AU - Russell, S. J.

AU - Peng, K. W.

N1 - Funding Information: We thank Suzanne Greiner (Mayo Clinic) for her veterinary expertise, Michael K O’Connor (Radiology, Mayo Clinic) for critical review of the manuscript, Tracy Decklever and Brad Kemp (Radiology, Mayo Clinic) of the Mayo Clinic Small Animal Imaging Core. This work was supported by the Mayo Foundation and grants from the National Institutes of Health (R01CA129193, R01CA100634, R01CA129966).

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AB - Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

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KW - reporter gene

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Oral contrast enhances the resolution of in-life NIS reporter gene imaging

Abstract

Keywords

ASJC Scopus subject areas

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