Oral contrast enhances the resolution of in-life NIS reporter gene imaging

L. Suksanpaisan, L. Pham, S. McIvor, S. J. Russell, K. W. Peng

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

Original languageEnglish (US)
Pages (from-to)638-641
Number of pages4
JournalCancer Gene Therapy
Volume20
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • NIS
  • barium sulfate
  • oral contrast
  • perigastric
  • reporter gene

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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