Oral contrast enhances the resolution of in-life NIS reporter gene imaging

L. Suksanpaisan, L. Pham, S. McIvor, Stephen J Russell, Kah-Whye Peng

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

Original languageEnglish (US)
Pages (from-to)638-641
Number of pages4
JournalCancer Gene Therapy
Volume20
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Reporter Genes
Stomach
Barium Sulfate
Omentum
Gamma Rays
Masks
Diaphragm
Pancreas
Spleen
Lymph Nodes
Technology
Liver
Neoplasms
sodium-iodide symporter

Keywords

  • barium sulfate
  • NIS
  • oral contrast
  • perigastric
  • reporter gene

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Molecular Biology

Cite this

Oral contrast enhances the resolution of in-life NIS reporter gene imaging. / Suksanpaisan, L.; Pham, L.; McIvor, S.; Russell, Stephen J; Peng, Kah-Whye.

In: Cancer Gene Therapy, Vol. 20, No. 11, 11.2013, p. 638-641.

Research output: Contribution to journalArticle

Suksanpaisan, L. ; Pham, L. ; McIvor, S. ; Russell, Stephen J ; Peng, Kah-Whye. / Oral contrast enhances the resolution of in-life NIS reporter gene imaging. In: Cancer Gene Therapy. 2013 ; Vol. 20, No. 11. pp. 638-641.
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