TY - JOUR
T1 - Oral bisphosphonate therapy and osteonecrosis of the jaw
T2 - What to tell the concerned patient
AU - Koka, Sreenivas
AU - Clarke, Bart L.
AU - Amin, Shreyasee
AU - Gertz, Morie
AU - Ruggiero, Salvatore L.
PY - 2007/3
Y1 - 2007/3
N2 - Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is encountered predominantly in cancer populations being treated with high-dose intravenous bisphosphonates for skeletal complications such as bone metastases and secondary fracture risk. A minority of BONJ lesions have been observed in patients receiving oral bisphosphonates for management of osteoporosis or osteopenia. In this paper, the current knowledge pertaining to the incidence, definition, and signs and symptoms of BONJ is presented, followed by a discussion of the incidence and consequences of osteoporotic skeletal fracture and the use of oral bisphosphonates to mitigate fracture. The risk of BONJ appears to be very small in patients taking oral bisphosphonates. In addition, the consequences of osteoporotic fracture likely have significantly greater mortality and morbidity than BONJ. Within this context, management concepts and guidelines are presented to help the dental clinician allay concerns about BONJ expressed by patients receiving oral bisphosphonate therapy.
AB - Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is encountered predominantly in cancer populations being treated with high-dose intravenous bisphosphonates for skeletal complications such as bone metastases and secondary fracture risk. A minority of BONJ lesions have been observed in patients receiving oral bisphosphonates for management of osteoporosis or osteopenia. In this paper, the current knowledge pertaining to the incidence, definition, and signs and symptoms of BONJ is presented, followed by a discussion of the incidence and consequences of osteoporotic skeletal fracture and the use of oral bisphosphonates to mitigate fracture. The risk of BONJ appears to be very small in patients taking oral bisphosphonates. In addition, the consequences of osteoporotic fracture likely have significantly greater mortality and morbidity than BONJ. Within this context, management concepts and guidelines are presented to help the dental clinician allay concerns about BONJ expressed by patients receiving oral bisphosphonate therapy.
UR - http://www.scopus.com/inward/record.url?scp=34047235731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047235731&partnerID=8YFLogxK
M3 - Article
C2 - 17455429
AN - SCOPUS:34047235731
SN - 0893-2174
VL - 20
SP - 115
EP - 122
JO - International Journal of Prosthodontics
JF - International Journal of Prosthodontics
IS - 2
ER -