Oral anticoagulation in the hospital: Analysis of patients at risk

Nancy L. Dawson, Dusko Klipa, Angela K. O'Brien, Juliana Crook, Melanie W. Cucchi, Alden K. Valentino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Warfarin is one of the most commonly used medications associated with adverse events. Warfarin therapy is often initiated or continued in the hospital, yet hospitalization increases the risk of poor anticoagulation control with warfarin. To help understand this, we retrospectively reviewed the records of patients admitted to our hospital during a 6-month period who were given at least one dose of warfarin. To explore factors that may have contributed to poor anticoagulation control, we compared characteristics of patients with an international normalized ratio (INR) ≥5 at some point during hospitalization with those of a group of matched controls who also received warfarin and had INR <5. Among the 35 patients identified who had an INR ≥5, concomitant use of antibiotics was more common than among 105 matched controls; improper warfarin dosing also appeared to contribute to the high INRs. These findings indicate possible targets for intervention to improve patient safety.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Volume31
Issue number1
DOIs
StatePublished - Jan 2011

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Warfarin
International Normalized Ratio
Hospitalization
Patient Safety
Research Design
Anti-Bacterial Agents
Control Groups

Keywords

  • Anticoagulation
  • Hospitalization
  • International normalized ratio (INR)
  • Warfarin

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Dawson, N. L., Klipa, D., O&apos;Brien, A. K., Crook, J., Cucchi, M. W., & Valentino, A. K. (2011). Oral anticoagulation in the hospital: Analysis of patients at risk. Journal of Thrombosis and Thrombolysis, 31(1), 22-26. https://doi.org/10.1007/s11239-010-0473-5

Oral anticoagulation in the hospital : Analysis of patients at risk. / Dawson, Nancy L.; Klipa, Dusko; O&apos;Brien, Angela K.; Crook, Juliana; Cucchi, Melanie W.; Valentino, Alden K.

In: Journal of Thrombosis and Thrombolysis, Vol. 31, No. 1, 01.2011, p. 22-26.

Research output: Contribution to journalArticle

Dawson, NL, Klipa, D, O&apos;Brien, AK, Crook, J, Cucchi, MW & Valentino, AK 2011, 'Oral anticoagulation in the hospital: Analysis of patients at risk', Journal of Thrombosis and Thrombolysis, vol. 31, no. 1, pp. 22-26. https://doi.org/10.1007/s11239-010-0473-5
Dawson, Nancy L. ; Klipa, Dusko ; O&apos;Brien, Angela K. ; Crook, Juliana ; Cucchi, Melanie W. ; Valentino, Alden K. / Oral anticoagulation in the hospital : Analysis of patients at risk. In: Journal of Thrombosis and Thrombolysis. 2011 ; Vol. 31, No. 1. pp. 22-26.
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