Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial brillation and no history of stroke or transient ischemic attacks

Maria I. Aguilar, R. Hart, L. A. Pearce

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To characterize the relative effect of long-term oral anticoagulant treatment versus antiplatelet therapy on major vascular events in patients with non-valvular AF and no history of stroke or TIA. Our main hypotheses are: (1) oral anticoagulant treatment compared to antiplatelet therapy will reduce ischemic events: ischemic strokes, myocardial infarction, systemic emboli, and vascular death (with a smaller decrease in all-cause death); (2) oral anticoagulant treatment compared to antiplatelet therapy will increase bleeding events: intracranial hemorrhage and major extracranial hemorrhage; (3) oral anticoagulant treatment compared to antiplatelet therapy will decrease clinically relevant combinations of ischemic plus bleeding events: all stroke (ischemic and hemorrhagic), disabling or fatal stroke (ischemic and hemorrhagic), and the composite of all stroke, myocardial infarction or vascular death.

Original languageEnglish (US)
Article numberCD006186
JournalCochrane Database of Systematic Reviews
Issue number4
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Pharmacology (medical)

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