Optimizing treatment outcomeswith regorafenib: Personalized dosing and other strategies to support patient care

Axel Grothey, Suzanne George, Eric van Cutsem, Jean Yves Blay, Alberto Sobrero, George D. Demetri

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Regorafenib is an oral multikinase inhibitor that inhibits several kinases relevant to tumor biology in several cancers, including colorectal carcinoma (CRC) and gastrointestinal stromal tumor (GIST). In phase III trials, regorafenib significantly improved overall survival versus placebo in patients with metastatic CRC progressing after all available standard therapies, and significantly prolonged progression-free survival in patients with advanced GIST in whom at least imatinib and sunitinib had failed. Thus, this agent holds promise as a new standard of care for CRC and GIST patients after disease progression following all other approved therapies.The clinical trials reported to date show that this new treatment has a consistent adverse event profile that is quite different from that of traditional cytotoxic chemotherapies. The most common adverse events of regorafenib include dermatologic and mucosal toxicities (especially hand-foot skin reaction, rash, and oral mucositis), constitutional symptoms (e.g., fatigue, nausea, and weight loss), vascular effects (especially hypertension), and gastrointestinal symptoms (e.g., diarrhea). To help health care professionals anticipate and manage the adverse events associated with regorafenib, we describe our experiences in clinical trials and show that such toxicities can be effectively managed with close observation of patients from initiation of dosing, along with prompt appropriate interventions, including dose modifications, if necessary.

Original languageEnglish (US)
Pages (from-to)669-680
Number of pages12
JournalOncologist
Volume19
Issue number6
DOIs
StatePublished - 2014

Keywords

  • Adverse events
  • Dose optimization
  • Hand-foot skin reaction
  • Multikinase inhibitor
  • Regorafenib
  • Supportive management

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Grothey, A., George, S., van Cutsem, E., Blay, J. Y., Sobrero, A., & Demetri, G. D. (2014). Optimizing treatment outcomeswith regorafenib: Personalized dosing and other strategies to support patient care. Oncologist, 19(6), 669-680. https://doi.org/10.1634/theoncologist.2013-0059