Abstract
We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient's lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 727-738 |
| Number of pages | 12 |
| Journal | European Journal of Operational Research |
| Volume | 233 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 16 2014 |
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Keywords
- Blood pressure treatment
- Cholesterol treatment
- Markov decision process
- OR in medicine
- Type 2 diabetes
ASJC Scopus subject areas
- Management Science and Operations Research
- Modeling and Simulation
- Information Systems and Management
Cite this
Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients. / Mason, J. E.; Denton, B. T.; Shah, Nilay D; Smith, S. A.
In: European Journal of Operational Research, Vol. 233, No. 3, 16.03.2014, p. 727-738.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients
AU - Mason, J. E.
AU - Denton, B. T.
AU - Shah, Nilay D
AU - Smith, S. A.
PY - 2014/3/16
Y1 - 2014/3/16
N2 - We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient's lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment.
AB - We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient's lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment.
KW - Blood pressure treatment
KW - Cholesterol treatment
KW - Markov decision process
KW - OR in medicine
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84888353064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888353064&partnerID=8YFLogxK
U2 - 10.1016/j.ejor.2013.09.018
DO - 10.1016/j.ejor.2013.09.018
M3 - Article
AN - SCOPUS:84888353064
VL - 233
SP - 727
EP - 738
JO - European Journal of Operational Research
JF - European Journal of Operational Research
SN - 0377-2217
IS - 3
ER -