Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients

J. E. Mason, B. T. Denton, N. D. Shah, S. A. Smith

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient's lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment.

Original languageEnglish (US)
Pages (from-to)727-738
Number of pages12
JournalEuropean Journal of Operational Research
Volume233
Issue number3
DOIs
StatePublished - Mar 16 2014

Keywords

  • Blood pressure treatment
  • Cholesterol treatment
  • Markov decision process
  • OR in medicine
  • Type 2 diabetes

ASJC Scopus subject areas

  • Computer Science(all)
  • Modeling and Simulation
  • Management Science and Operations Research
  • Information Systems and Management

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