Abstract
We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient's lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 727-738 |
| Number of pages | 12 |
| Journal | European Journal of Operational Research |
| Volume | 233 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 16 2014 |
Keywords
- Blood pressure treatment
- Cholesterol treatment
- Markov decision process
- OR in medicine
- Type 2 diabetes
ASJC Scopus subject areas
- Computer Science(all)
- Modeling and Simulation
- Management Science and Operations Research
- Information Systems and Management
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Mason, J. E., Denton, B. T., Shah, N. D., & Smith, S. A. (2014). Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients. European Journal of Operational Research, 233(3), 727-738. https://doi.org/10.1016/j.ejor.2013.09.018