Abstract
Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two- stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 763-772 |
| Number of pages | 10 |
| Journal | Biometrics |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1993 |
Fingerprint
ASJC Scopus subject areas
- Statistics and Probability
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics
Cite this
Brittain, E. H., & Bailey, K. R. (1993). Optimization of multistage testing times and critical values in clinical trials. Biometrics, 49(3), 763-772. https://doi.org/10.2307/2532197