Optimization of multistage testing times and critical values in clinical trials

E. H. Brittain, Kent R Bailey

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two- stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
JournalBiometrics
Volume49
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Clinical Trials
Sample Size
Critical value
clinical trials
Optimality
Robustness
Minimise
Testing
Optimization
testing
sampling
Model

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Statistics and Probability
  • Public Health, Environmental and Occupational Health

Cite this

Optimization of multistage testing times and critical values in clinical trials. / Brittain, E. H.; Bailey, Kent R.

In: Biometrics, Vol. 49, No. 3, 1993, p. 763-772.

Research output: Contribution to journalArticle

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