Optimization of multistage testing times and critical values in clinical trials

E. H. Brittain, K. R. Bailey

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two- stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
JournalBiometrics
Volume49
Issue number3
DOIs
StatePublished - Jan 1 1993

    Fingerprint

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this