Optimization of multistage testing times and critical values in clinical trials

E. H. Brittain, K. R. Bailey

Research output: Contribution to journalArticle

14 Scopus citations


Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two- stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
Issue number3
StatePublished - Jan 1 1993


ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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