Optimal treatment of multiple ipsilateral primary breast cancers

Susanne Carpenter, Jason Fraser, Mark Fleming, Richard Gray, Michele Halyard, Barbara A Pockaj

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. Methods: A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cancer with additional in situ lesions and those receiving neoadjuvant therapy were excluded. Results: One hundred forty-nine patients were treated over 19 years. Fifty-eight (39%) patients underwent BCT. Preoperatively, multiple tumors were suspected in more mastectomy patients than BCT patients (75% versus 62%). Most patients had 2 tumors and 1 histology. Fifty-five percent of patients with tumors within 1 quadrant underwent BCT versus 10% of patients with tumors in more than 1 quadrant. One hundred eight patients underwent sentinel lymph node (SLN) biopsy. Twenty-seven percent (34) were SLN positive. There were no regional recurrences among the SLN-negative patients. Six patients recurred: 1 nodal, 1 local, and 4 distant. The locoregional BCT recurrence rate was 3.4%. Discussion: MIBC patients can safely undergo BCT with low recurrence risk. SLNB can be performed with minimal risk of regional recurrence.

Original languageEnglish (US)
Pages (from-to)530-536
Number of pages7
JournalAmerican Journal of Surgery
Volume196
Issue number4
DOIs
StatePublished - Oct 2008

Fingerprint

Breast Neoplasms
Segmental Mastectomy
Therapeutics
Recurrence
Neoplasms
Sentinel Lymph Node Biopsy
Neoadjuvant Therapy
Mastectomy
Histology
Breast

Keywords

  • Breast cancer
  • Breast-conservation therapy
  • Multicentric
  • Multifocal
  • Multiple ipsilateral
  • Segmental mastectomy
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Surgery

Cite this

Optimal treatment of multiple ipsilateral primary breast cancers. / Carpenter, Susanne; Fraser, Jason; Fleming, Mark; Gray, Richard; Halyard, Michele; Pockaj, Barbara A.

In: American Journal of Surgery, Vol. 196, No. 4, 10.2008, p. 530-536.

Research output: Contribution to journalArticle

Carpenter, Susanne ; Fraser, Jason ; Fleming, Mark ; Gray, Richard ; Halyard, Michele ; Pockaj, Barbara A. / Optimal treatment of multiple ipsilateral primary breast cancers. In: American Journal of Surgery. 2008 ; Vol. 196, No. 4. pp. 530-536.
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