Abstract
Introduction: The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. Methods: A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cancer with additional in situ lesions and those receiving neoadjuvant therapy were excluded. Results: One hundred forty-nine patients were treated over 19 years. Fifty-eight (39%) patients underwent BCT. Preoperatively, multiple tumors were suspected in more mastectomy patients than BCT patients (75% versus 62%). Most patients had 2 tumors and 1 histology. Fifty-five percent of patients with tumors within 1 quadrant underwent BCT versus 10% of patients with tumors in more than 1 quadrant. One hundred eight patients underwent sentinel lymph node (SLN) biopsy. Twenty-seven percent (34) were SLN positive. There were no regional recurrences among the SLN-negative patients. Six patients recurred: 1 nodal, 1 local, and 4 distant. The locoregional BCT recurrence rate was 3.4%. Discussion: MIBC patients can safely undergo BCT with low recurrence risk. SLNB can be performed with minimal risk of regional recurrence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 530-536 |
| Number of pages | 7 |
| Journal | American Journal of Surgery |
| Volume | 196 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2008 |
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Keywords
- Breast cancer
- Breast-conservation therapy
- Multicentric
- Multifocal
- Multiple ipsilateral
- Segmental mastectomy
- Sentinel lymph node biopsy
ASJC Scopus subject areas
- Surgery
Cite this
Optimal treatment of multiple ipsilateral primary breast cancers. / Carpenter, Susanne; Fraser, Jason; Fleming, Mark; Gray, Richard; Halyard, Michele; Pockaj, Barbara A.
In: American Journal of Surgery, Vol. 196, No. 4, 10.2008, p. 530-536.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimal treatment of multiple ipsilateral primary breast cancers
AU - Carpenter, Susanne
AU - Fraser, Jason
AU - Fleming, Mark
AU - Gray, Richard
AU - Halyard, Michele
AU - Pockaj, Barbara A
PY - 2008/10
Y1 - 2008/10
N2 - Introduction: The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. Methods: A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cancer with additional in situ lesions and those receiving neoadjuvant therapy were excluded. Results: One hundred forty-nine patients were treated over 19 years. Fifty-eight (39%) patients underwent BCT. Preoperatively, multiple tumors were suspected in more mastectomy patients than BCT patients (75% versus 62%). Most patients had 2 tumors and 1 histology. Fifty-five percent of patients with tumors within 1 quadrant underwent BCT versus 10% of patients with tumors in more than 1 quadrant. One hundred eight patients underwent sentinel lymph node (SLN) biopsy. Twenty-seven percent (34) were SLN positive. There were no regional recurrences among the SLN-negative patients. Six patients recurred: 1 nodal, 1 local, and 4 distant. The locoregional BCT recurrence rate was 3.4%. Discussion: MIBC patients can safely undergo BCT with low recurrence risk. SLNB can be performed with minimal risk of regional recurrence.
AB - Introduction: The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. Methods: A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cancer with additional in situ lesions and those receiving neoadjuvant therapy were excluded. Results: One hundred forty-nine patients were treated over 19 years. Fifty-eight (39%) patients underwent BCT. Preoperatively, multiple tumors were suspected in more mastectomy patients than BCT patients (75% versus 62%). Most patients had 2 tumors and 1 histology. Fifty-five percent of patients with tumors within 1 quadrant underwent BCT versus 10% of patients with tumors in more than 1 quadrant. One hundred eight patients underwent sentinel lymph node (SLN) biopsy. Twenty-seven percent (34) were SLN positive. There were no regional recurrences among the SLN-negative patients. Six patients recurred: 1 nodal, 1 local, and 4 distant. The locoregional BCT recurrence rate was 3.4%. Discussion: MIBC patients can safely undergo BCT with low recurrence risk. SLNB can be performed with minimal risk of regional recurrence.
KW - Breast cancer
KW - Breast-conservation therapy
KW - Multicentric
KW - Multifocal
KW - Multiple ipsilateral
KW - Segmental mastectomy
KW - Sentinel lymph node biopsy
UR - http://www.scopus.com/inward/record.url?scp=52049093918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52049093918&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2008.06.025
DO - 10.1016/j.amjsurg.2008.06.025
M3 - Article
VL - 196
SP - 530
EP - 536
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 4
ER -