Abstract
Introduction: The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. Methods: A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cancer with additional in situ lesions and those receiving neoadjuvant therapy were excluded. Results: One hundred forty-nine patients were treated over 19 years. Fifty-eight (39%) patients underwent BCT. Preoperatively, multiple tumors were suspected in more mastectomy patients than BCT patients (75% versus 62%). Most patients had 2 tumors and 1 histology. Fifty-five percent of patients with tumors within 1 quadrant underwent BCT versus 10% of patients with tumors in more than 1 quadrant. One hundred eight patients underwent sentinel lymph node (SLN) biopsy. Twenty-seven percent (34) were SLN positive. There were no regional recurrences among the SLN-negative patients. Six patients recurred: 1 nodal, 1 local, and 4 distant. The locoregional BCT recurrence rate was 3.4%. Discussion: MIBC patients can safely undergo BCT with low recurrence risk. SLNB can be performed with minimal risk of regional recurrence.
Original language | English (US) |
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Pages (from-to) | 530-536 |
Number of pages | 7 |
Journal | American journal of surgery |
Volume | 196 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2008 |
Keywords
- Breast cancer
- Breast-conservation therapy
- Multicentric
- Multifocal
- Multiple ipsilateral
- Segmental mastectomy
- Sentinel lymph node biopsy
ASJC Scopus subject areas
- Surgery