Optimal management of skin cancer in immunosuppressed patients

Lauren Brin, Adeel S. Zubair, Jerry D. Brewer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Skin cancer is the most common malignancy in humans with basal cell carcinoma representing the majority of cases in the general population. The prevalence of skin cancer is increased amongst immunosuppressed patients such as those with lymphoproliferative disorders including non-Hodgkin lymphoma and chronic lymphocytic leukemia or those with iatrogenic immunosuppression following organ transplantation. In addition, these patients experience greater morbidity and mortality associated with skin cancers. The most common skin cancer in immunosuppressed patients is squamous cell carcinoma, which often presents with more aggressive features and has a greater rate of metastasis. This article reviews the risk factors, etiology, clinical presentation, and prevalence of skin cancer amongst immunosuppressed patients, including organ transplant, lymphoproliferative disorders, autoimmune disorders, and human immunodeficiency virus. We also provide a comprehensive review of treatment guidelines for immunosuppressed patients with cutaneous malignancy. Surgical therapy is the cornerstone of treatment; however, we also discuss pharmacologic treatment options, lifestyle modifications, and revision of immunosuppressive regimens.

Original languageEnglish (US)
Pages (from-to)339-356
Number of pages18
JournalAmerican Journal of Clinical Dermatology
Volume15
Issue number4
DOIs
StatePublished - 2014

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Skin Neoplasms
Lymphoproliferative Disorders
Basal Cell Carcinoma
Organ Transplantation
B-Cell Chronic Lymphocytic Leukemia
Therapeutics
Immunosuppressive Agents
Non-Hodgkin's Lymphoma
Immunosuppression
Life Style
Squamous Cell Carcinoma
Neoplasms
HIV
Guidelines
Neoplasm Metastasis
Morbidity
Transplants
Skin
Mortality
Population

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Optimal management of skin cancer in immunosuppressed patients. / Brin, Lauren; Zubair, Adeel S.; Brewer, Jerry D.

In: American Journal of Clinical Dermatology, Vol. 15, No. 4, 2014, p. 339-356.

Research output: Contribution to journalArticle

Brin, Lauren ; Zubair, Adeel S. ; Brewer, Jerry D. / Optimal management of skin cancer in immunosuppressed patients. In: American Journal of Clinical Dermatology. 2014 ; Vol. 15, No. 4. pp. 339-356.
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