Abstract
Our nuclear pharmacy has reported that a failed radiochemical purity (RCP) (i.e., RCP <90%) of 99mTc sestamibi may be associated with the use of a first elution at later stages from a long-ingrowth time (i.e., ≤72 h) wet-column generator. The primary purpose of this study was to evaluate the effects of 99mTc eluates from wet and dry column generators on the RCP of 99mTc-sestamibi under the above conditions. RCP values were found to be measurably higher and kit failure rates lower with the use of dry-column generator eluate. Using a dry-column generator eluate, Cardiolite® kits were prepared with 11.10 GBq of 99mTc at 3, 4, and 5 h postelution and 5.55 GBq at 6, 10, 11, and 12 h postelution. Our data suggest that when 11.10 GBq of 99mTc from a dry column generator with ≤72-h ingrowth was used to prepare 99mTc sestamibi, kit failure started to occur using 99mTc eluate at approximately 4 h postelution. When 5.55 GBq was used to reconstitute the kit, RCP failure began to occur using 99mTc eluate ~10 h postelution and was likely to occur by 12 h postelution. Dry column generator eluates have lower kit failures than do wet column generators; the failure rate can be reduced even further by avoiding the addition of high activities of 99mTc and long elution times.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 599-603 |
| Number of pages | 5 |
| Journal | Nuclear Medicine and Biology |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jul 1996 |
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Keywords
- Tc-sestamibi
- Dry column generator
- Eluate age
- Long ingrowth time of Tc eluate
- Radiochemical purity
- Wet-column generator
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
Optimal conditions of 99mTc eluate for the radiolabeling of 99mTc-sestamibi. / Hung, Joseph C.; Herold, Thomas J.; Gibbons, Raymond J.
In: Nuclear Medicine and Biology, Vol. 23, No. 5, 07.1996, p. 599-603.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimal conditions of 99mTc eluate for the radiolabeling of 99mTc-sestamibi
AU - Hung, Joseph C.
AU - Herold, Thomas J.
AU - Gibbons, Raymond J
PY - 1996/7
Y1 - 1996/7
N2 - Our nuclear pharmacy has reported that a failed radiochemical purity (RCP) (i.e., RCP <90%) of 99mTc sestamibi may be associated with the use of a first elution at later stages from a long-ingrowth time (i.e., ≤72 h) wet-column generator. The primary purpose of this study was to evaluate the effects of 99mTc eluates from wet and dry column generators on the RCP of 99mTc-sestamibi under the above conditions. RCP values were found to be measurably higher and kit failure rates lower with the use of dry-column generator eluate. Using a dry-column generator eluate, Cardiolite® kits were prepared with 11.10 GBq of 99mTc at 3, 4, and 5 h postelution and 5.55 GBq at 6, 10, 11, and 12 h postelution. Our data suggest that when 11.10 GBq of 99mTc from a dry column generator with ≤72-h ingrowth was used to prepare 99mTc sestamibi, kit failure started to occur using 99mTc eluate at approximately 4 h postelution. When 5.55 GBq was used to reconstitute the kit, RCP failure began to occur using 99mTc eluate ~10 h postelution and was likely to occur by 12 h postelution. Dry column generator eluates have lower kit failures than do wet column generators; the failure rate can be reduced even further by avoiding the addition of high activities of 99mTc and long elution times.
AB - Our nuclear pharmacy has reported that a failed radiochemical purity (RCP) (i.e., RCP <90%) of 99mTc sestamibi may be associated with the use of a first elution at later stages from a long-ingrowth time (i.e., ≤72 h) wet-column generator. The primary purpose of this study was to evaluate the effects of 99mTc eluates from wet and dry column generators on the RCP of 99mTc-sestamibi under the above conditions. RCP values were found to be measurably higher and kit failure rates lower with the use of dry-column generator eluate. Using a dry-column generator eluate, Cardiolite® kits were prepared with 11.10 GBq of 99mTc at 3, 4, and 5 h postelution and 5.55 GBq at 6, 10, 11, and 12 h postelution. Our data suggest that when 11.10 GBq of 99mTc from a dry column generator with ≤72-h ingrowth was used to prepare 99mTc sestamibi, kit failure started to occur using 99mTc eluate at approximately 4 h postelution. When 5.55 GBq was used to reconstitute the kit, RCP failure began to occur using 99mTc eluate ~10 h postelution and was likely to occur by 12 h postelution. Dry column generator eluates have lower kit failures than do wet column generators; the failure rate can be reduced even further by avoiding the addition of high activities of 99mTc and long elution times.
KW - Tc-sestamibi
KW - Dry column generator
KW - Eluate age
KW - Long ingrowth time of Tc eluate
KW - Radiochemical purity
KW - Wet-column generator
UR - http://www.scopus.com/inward/record.url?scp=0030176621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030176621&partnerID=8YFLogxK
U2 - 10.1016/0969-8051(96)00054-6
DO - 10.1016/0969-8051(96)00054-6
M3 - Article
C2 - 9044686
AN - SCOPUS:0030176621
VL - 23
SP - 599
EP - 603
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 5
ER -