Optimal acquisition setting for dual-contrast imaging with gadolinium and iodine on a research whole-body photon-counting-detector (PCD) CT

Shengzhen Tao, Yizhong Wu, Kishore Rajendran, Cynthia H McCollough, Shuai Leng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Photon-counting detectors (PCDs) can resolve the energy of incident x-ray photons, which allows simultaneous imaging of two contrast materials, such as iodine (I) and gadolinium (Gd), with a single scan. This capability may allow reduction of patient radiation dose for clinical applications that typically require multi-phase acquisitions by injecting different contrast media at different times and scanning only once to differentiate, for example, venous and arterial phases. The material decomposition performance on PCD-CT is dependent on acquisition setup including tube potential and energy thresholds. In this work, we performed a phantom study to evaluate the optimal acquisition settings for dual-contrast imaging using I and Gd on a research PCD-CT system. We further compared our results with a clinical dual-source dual-energy (DSDE) CT. An abdomen-shaped water phantom with I and Gd inserts of different concentrations was scanned using different energy thresholds and tube potentials to identify the optimal setup for I and Gd quantification. Results demonstrated that accurate quantification of I and Gd concentration was possible using the PCD-CT system. A tube potential of 80 kV and an energy threshold close to the K-edge of Gd (50 keV) was found to yield the best performance in terms of measurement root-mean-square-error (RMSE = 4.4 mg/mL for I and RMSE = 3.3 mg/mL for Gd). Further, the performance of PCD-CT with optimized setup was found to outperform DSDE-CT (RMSE = 8.1 mg/mL for I and 5.7 mg/mL for Gd).

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationPhysics of Medical Imaging
EditorsHilde Bosmans, Guang-Hong Chen, Taly Gilat Schmidt
PublisherSPIE
ISBN (Electronic)9781510625433
DOIs
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Physics of Medical Imaging - San Diego, United States
Duration: Feb 17 2019Feb 20 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10948
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2019: Physics of Medical Imaging
CountryUnited States
CitySan Diego
Period2/17/192/20/19

Keywords

  • Computed tomography
  • Dual-contrast imaging
  • Multi-energy CT
  • Photon-counting detectors
  • Spectral CT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tao, S., Wu, Y., Rajendran, K., McCollough, C. H., & Leng, S. (2019). Optimal acquisition setting for dual-contrast imaging with gadolinium and iodine on a research whole-body photon-counting-detector (PCD) CT. In H. Bosmans, G-H. Chen, & T. G. Schmidt (Eds.), Medical Imaging 2019: Physics of Medical Imaging [109484I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10948). SPIE. https://doi.org/10.1117/12.2513454