Optical spectroscopy for the detection of dysplasia in Barrett's esophagus

Louis Michel Wong Kee Song

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Patients with Barrett's esophagus (BE) undergo periodic endoscopic surveillance with multiple biopsy examinations in an attempt to identify dysplastic and early cancerous lesions at a time when intervention can be beneficial. However, this surveillance approach is hindered by low sampling yield, random sampling error, pathology-associated costs, and delay in diagnosis. Optical spectroscopy offers the potential to identify tissue pathology accurately in real time. The technique uses diagnostic molecular and/or microstructural information contained in light-tissue interactions such as fluorescence, elastic scattering, and inelastic (Raman) scattering. As an adjunct to endoscopy, optical spectroscopy has the capacity to enhance lesion detection in premalignant conditions such as BE. This article highlights the current status and future prospects of optical spectroscopy in BE.

Original languageEnglish (US)
Pages (from-to)S2-S7
JournalClinical Gastroenterology and Hepatology
Volume3
Issue number7 SUPPL.
DOIs
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Optical spectroscopy for the detection of dysplasia in Barrett's esophagus'. Together they form a unique fingerprint.

  • Cite this