Optic chiasm involvement in AQP-4 antibody–positive NMO and MOG antibody–associated disorder

Deena Tajfirouz, Tanyatuth Padungkiatsagul, Shannon Beres, Heather E. Moss, Sean Pittock, Eoin Flanagan, Amy Kunchok, Shailee Shah, M. Tariq Bhatti, John J. Chen

Research output: Contribution to journalArticlepeer-review


Background: Optic neuritis (ON) is often the presenting symptom in inflammatory central nervous system demyelinating disorders. Objective: To compare the frequency and pattern of optic chiasm involvement in patients with aquaporin-4-immunoglobulin G (AQP4-IgG)-associated ON to patients with myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated ON. Methods: Retrospective review of all patients evaluated at Mayo Clinic, Stanford University and Ramathibodi Hospital who were found to have: (1) ON, (2) either MOG-IgG or AQP4-IgG by cell-based assay, and (3) magnetic resonance imaging (MRI) at the time of ON. MRI was reviewed for contrast enhancement of the optic chiasm and the pattern of involvement. Results: One hundred and fifty-four patients (74 AQP4-IgG and 80 MOG-IgG) were included. Among patients with AQP4-IgG-ON, 20% had chiasmal involvement, compared with 16% of patients with MOG-IgG-ON (p = 0.66). In patients with chiasmal involvement, longitudinally extensive optic nerve enhancement (from orbit extending to chiasm) was identified in 54% of MOG-IgG-ON patients, compared with 7% of AQP4-IgG-ON patients (p = 0.01). Conclusion: Chiasmal involvement of MOG-IgG-ON and AQP4-IgG-ON occur at more similar frequencies than previously reported. Furthermore, MOG-IgG-ON chiasmal involvement is more likely to be part of a longitudinally extensive optic nerve lesion.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalMultiple Sclerosis Journal
Issue number1
StatePublished - Jan 2022


  • Demyelination
  • MRI
  • neuromyelitis optica
  • relapsing or remitting

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Optic chiasm involvement in AQP-4 antibody–positive NMO and MOG antibody–associated disorder'. Together they form a unique fingerprint.

Cite this