Opposing roles of dectin-1 expressed on human plasmacytoid dendritic cells and myeloid dendritic cells in TH2 polarization

Hye Mee Joo, Katherine Upchurch, Wei Zhang, Ling Ni, Dapeng Li, Yaming Xue, Xiao Hua Li, Toshiyuki Hori, Sandra Zurawski, Yong Jun Liu, Gerard Zurawski, Sang Kon Oh

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Dendritic cells (DCs) can induce and control host immune responses. DC subset-dependent functional specialties and their ability to display functional plasticity, which is mainly driven by signals via pattern recognition receptors, identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1-activated plasmacytoid DCs promote TH2-type T cell responses, whereas Dectin-1-activated myeloid DCs decrease TH2-type T cell responses. Such contrasting outcomes of TH2- type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to b-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.

Original languageEnglish (US)
Pages (from-to)1723-1731
Number of pages9
JournalJournal of Immunology
Volume195
Issue number4
DOIs
StatePublished - Aug 15 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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