TY - JOUR
T1 - Opportunities and challenges in heart rhythm research
T2 - Rationale and development of an electrophysiology collaboratory
AU - Nguyen, Duy T.
AU - Bilchick, Kenneth C.
AU - Narayan, Sanjiv M.
AU - Chung, Mina K.
AU - Thomas, Kevin L.
AU - Laurita, Kenneth R.
AU - Vaseghi, Marmar
AU - Sandhu, Roopinder
AU - Chelu, Mihail G.
AU - Kannankeril, Prince J.
AU - Packer, Douglas L.
AU - McManus, David D.
AU - Verma, Atul
AU - Singleton, Matthew
AU - Tarakji, Khaldoun
AU - Al-Khatib, Sana M.
AU - Kaltman, Jonathan R.
AU - Balijepalli, Ravi C.
AU - Van Hare, George F.
AU - Hurwitz, Jodie L.
AU - Russo, Andrea M.
AU - Kusumoto, Fred M.
AU - Albert, Christine M.
N1 - Publisher Copyright:
© 2022 Heart Rhythm Society
PY - 2022/11
Y1 - 2022/11
N2 - There are many challenges in the current landscape of electrophysiology (EP) clinical and translational research, including increasing costs and complexity, competing demands, regulatory requirements, and challenges with study implementation. This review seeks to broadly discuss the state of EP research, including challenges and opportunities. Included here are results from a Heart Rhythm Society (HRS) Research Committee member survey detailing HRS members’ perspectives regarding both barriers to clinical and translational research and opportunities to address these challenges. We also provide stakeholder perspectives on barriers and opportunities for future EP research, including input from representatives of the U.S. Food and Drug Administration, industry, and research funding institutions that participated in a Research Collaboratory Summit convened by HRS. This review further summarizes the experiences of the heart failure and heart valve communities and how they have approached similar challenges in their own fields. We then explore potential solutions, including various models of research ecosystems designed to identify research challenges and to coordinate ways to address them in a collaborative fashion in order to optimize innovation, increase efficiency of evidence generation, and advance the development of new therapeutic products. The objectives of the proposed collaborative cardiac EP research community are to encourage and support scientific discourse, research efficiency, and evidence generation by exploring collaborative and equitable solutions in which stakeholders within the EP community can interact to address knowledge gaps, innovate, and advance new therapies.
AB - There are many challenges in the current landscape of electrophysiology (EP) clinical and translational research, including increasing costs and complexity, competing demands, regulatory requirements, and challenges with study implementation. This review seeks to broadly discuss the state of EP research, including challenges and opportunities. Included here are results from a Heart Rhythm Society (HRS) Research Committee member survey detailing HRS members’ perspectives regarding both barriers to clinical and translational research and opportunities to address these challenges. We also provide stakeholder perspectives on barriers and opportunities for future EP research, including input from representatives of the U.S. Food and Drug Administration, industry, and research funding institutions that participated in a Research Collaboratory Summit convened by HRS. This review further summarizes the experiences of the heart failure and heart valve communities and how they have approached similar challenges in their own fields. We then explore potential solutions, including various models of research ecosystems designed to identify research challenges and to coordinate ways to address them in a collaborative fashion in order to optimize innovation, increase efficiency of evidence generation, and advance the development of new therapeutic products. The objectives of the proposed collaborative cardiac EP research community are to encourage and support scientific discourse, research efficiency, and evidence generation by exploring collaborative and equitable solutions in which stakeholders within the EP community can interact to address knowledge gaps, innovate, and advance new therapies.
KW - Collaborative community
KW - Collaboratory
KW - Electrophysiology
KW - Research opportunities
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U2 - 10.1016/j.hrthm.2022.08.004
DO - 10.1016/j.hrthm.2022.08.004
M3 - Article
C2 - 37850602
AN - SCOPUS:85140072816
SN - 1547-5271
VL - 19
SP - 1927
EP - 1945
JO - Heart rhythm
JF - Heart rhythm
IS - 11
ER -