Abstract
This article reviews the pharmacology and physiology of opiate receptors and the current and potential uses of opioid agonists and antagonists in clinical gastroenterology. μ-receptors are involved in motor and sensory functions, and their modulation is established for treatment of diarrhea. μ-antagonists have potential to reverse endogenous (e.g., post-operative ileus) or iatrogenic dysmotility (e.g., opioid bowel dysfunction). Modulation of the function of κ-receptors may be a novel approach to control visceral pain in functional gut disorders. Results of formal testing of novel opioid modulators are keenly awaited.
Original language | English (US) |
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Pages (from-to) | 383-394 |
Number of pages | 12 |
Journal | Neurogastroenterology and Motility |
Volume | 16 |
Issue number | 4 |
DOIs | |
State | Published - Sep 2004 |
Keywords
- Absorption
- Mobility
- Opiate
- Opioid
- Receptor
- Sensation
ASJC Scopus subject areas
- Physiology
- Endocrine and Autonomic Systems
- Gastroenterology