Opioids and the gut: Pharmacology and current clinical experience

H. U. De Schepper, F. Cremonini, M. I. Park, Michael Camilleri

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

This article reviews the pharmacology and physiology of opiate receptors and the current and potential uses of opioid agonists and antagonists in clinical gastroenterology. μ-receptors are involved in motor and sensory functions, and their modulation is established for treatment of diarrhea. μ-antagonists have potential to reverse endogenous (e.g., post-operative ileus) or iatrogenic dysmotility (e.g., opioid bowel dysfunction). Modulation of the function of κ-receptors may be a novel approach to control visceral pain in functional gut disorders. Results of formal testing of novel opioid modulators are keenly awaited.

Original languageEnglish (US)
Pages (from-to)383-394
Number of pages12
JournalNeurogastroenterology and Motility
Volume16
Issue number4
DOIs
StatePublished - Sep 2004

Fingerprint

Clinical Pharmacology
Opioid Analgesics
Visceral Pain
Narcotic Antagonists
Ileus
Opioid Receptors
Gastroenterology
Diarrhea
Pharmacology
Therapeutics

Keywords

  • Absorption
  • Mobility
  • Opiate
  • Opioid
  • Receptor
  • Sensation

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Opioids and the gut : Pharmacology and current clinical experience. / De Schepper, H. U.; Cremonini, F.; Park, M. I.; Camilleri, Michael.

In: Neurogastroenterology and Motility, Vol. 16, No. 4, 09.2004, p. 383-394.

Research output: Contribution to journalArticle

De Schepper, H. U. ; Cremonini, F. ; Park, M. I. ; Camilleri, Michael. / Opioids and the gut : Pharmacology and current clinical experience. In: Neurogastroenterology and Motility. 2004 ; Vol. 16, No. 4. pp. 383-394.
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