Open label trial of coenzyme Q10 as a migraine preventive

T. D. Rozen, M. L. Oshinsky, C. A. Gebeline, K. C. Bradley, W. B. Young, A. L. Shechter, S. D. Silberstein

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

The objective was to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. Thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with coenzyme Q10 at a dose of 150 mg per day. Thirty-one of 32 patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. The average number of days with migraine during the baseline period was 7.34 and this decreased to 2.95 after 3 months of therapy, which was a statistically significant response (P < 0.0001). Mean reduction in migraine frequency after 1 month of treatment was 13.1% and this increased to 55.3% by the end of 3 months. Mean migraine attack frequency was 4.85 during the baseline period and this decreased to 2.81 attacks by the end of the study period, which was a statistically significant response (P < 0.001). There were no side-effects noted with coenzyme Q10. From this open label investigation coenzyme Q10 appears to be a good migraine preventive. Placebo-controlled trials are now necessary to determine the true efficacy of coenzyme Q10 in migraine prevention.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalCephalalgia
Volume22
Issue number2
DOIs
StatePublished - May 20 2002

Keywords

  • Coenzyme Q10
  • Migraine
  • Mitochondria

ASJC Scopus subject areas

  • Clinical Neurology

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    Rozen, T. D., Oshinsky, M. L., Gebeline, C. A., Bradley, K. C., Young, W. B., Shechter, A. L., & Silberstein, S. D. (2002). Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia, 22(2), 137-141. https://doi.org/10.1046/j.1468-2982.2002.00335.x