Open chromatin in pluripotency and reprogramming

Alexandre Gaspar Maia, Adi Alajem, Eran Meshorer, Miguel Ramalho-Santos

Research output: Contribution to journalReview article

309 Citations (Scopus)

Abstract

Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.

Original languageEnglish (US)
Pages (from-to)36-47
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Chromatin
Pluripotent Stem Cells
Transcriptional Activation
Stem Cells
Embryonic Structures
Maintenance
Genes
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Open chromatin in pluripotency and reprogramming. / Gaspar Maia, Alexandre; Alajem, Adi; Meshorer, Eran; Ramalho-Santos, Miguel.

In: Nature Reviews Molecular Cell Biology, Vol. 12, No. 1, 01.01.2011, p. 36-47.

Research output: Contribution to journalReview article

Gaspar Maia, Alexandre ; Alajem, Adi ; Meshorer, Eran ; Ramalho-Santos, Miguel. / Open chromatin in pluripotency and reprogramming. In: Nature Reviews Molecular Cell Biology. 2011 ; Vol. 12, No. 1. pp. 36-47.
@article{90bcc581bdd74caf9f960011a95a280a,
title = "Open chromatin in pluripotency and reprogramming",
abstract = "Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.",
author = "{Gaspar Maia}, Alexandre and Adi Alajem and Eran Meshorer and Miguel Ramalho-Santos",
year = "2011",
month = "1",
day = "1",
doi = "10.1038/nrm3036",
language = "English (US)",
volume = "12",
pages = "36--47",
journal = "Nature Reviews Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Open chromatin in pluripotency and reprogramming

AU - Gaspar Maia, Alexandre

AU - Alajem, Adi

AU - Meshorer, Eran

AU - Ramalho-Santos, Miguel

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.

AB - Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.

UR - http://www.scopus.com/inward/record.url?scp=78650467973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650467973&partnerID=8YFLogxK

U2 - 10.1038/nrm3036

DO - 10.1038/nrm3036

M3 - Review article

C2 - 21179060

AN - SCOPUS:78650467973

VL - 12

SP - 36

EP - 47

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

SN - 1471-0072

IS - 1

ER -