One size does not fit all - Regional variation in the impact of the share 35 liver allocation policy

K. J. Halazun, Amit Mathur, A. A. Rana, A. B. Massie, S. Mohan, R. E. Patzer, J. P. Wedd, B. Samstein, R. M. Subramanian, B. D. Campos, S. J. Knechtle

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Allocation policies for liver transplantation underwent significant changes in June 2013 with the introduction of Share 35. We aimed to examine the effect of Share 35 on regional variation in posttransplant outcomes. We examined two patient groups from the United Network for Organ Sharing dataset; a pre-Share 35 group composed of patients transplanted between June 17, 2012, and June 17, 2013 (n = 5523), and a post-Share group composed of patients transplanted between June 18, 2013, and June 18, 2014 (n = 5815). We used Kaplan-Meier and Cox multivariable analyses to compare survival. There were significant increases in allocation Model for End-stage Liver Disease (MELD) scores, laboratory MELD scores, and proportions of patients in the intensive care unit and on mechanical, ventilated, or organ-perfusion support at transplant post-Share 35. We also observed a significant increase in donor risk index in this group. We found no difference on a national level in survival between patients transplanted pre-Share 35 and post-Share 35 (p = 0.987). Regionally, however, posttransplantation survival was significantly worse in the post-Share 35 patients in regions 4 and 10 (p = 0.008 and p = 0.04), with no significant differences in the remaining regions. These results suggest that Share 35 has been associated with transplanting "sicker patients" with higher MELD scores, and although no difference in survival is observed on a national level, outcomes appear to be concerning in some regions. This study examines the impact of the Share 35 liver allocation policy, with specific emphasis on regional variability in patient characteristics and posttransplant survival before and after its implementation. See also the brief communication by Fernandez et al on page 287.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalAmerican Journal of Transplantation
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'One size does not fit all - Regional variation in the impact of the share 35 liver allocation policy'. Together they form a unique fingerprint.

  • Cite this

    Halazun, K. J., Mathur, A., Rana, A. A., Massie, A. B., Mohan, S., Patzer, R. E., Wedd, J. P., Samstein, B., Subramanian, R. M., Campos, B. D., & Knechtle, S. J. (2016). One size does not fit all - Regional variation in the impact of the share 35 liver allocation policy. American Journal of Transplantation, 16(1), 137-142. https://doi.org/10.1111/ajt.13500