Oncolytic measles virus strains in the treatment of gliomas

Cory Allen, Georgia Paraskevakou, Chunsheng Liu, Ianko D. Iankov, Pavlos Msaouel, Paula Zollman, Evanthia Galanis

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Background: Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy. Objective: In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas. Methods: Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described. Results/conclusions: Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Brain tumor
  • Engineering
  • Measles virus
  • Retargeting
  • Virotherapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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  • Cite this

    Allen, C., Paraskevakou, G., Liu, C., Iankov, I. D., Msaouel, P., Zollman, P., & Galanis, E. (2008). Oncolytic measles virus strains in the treatment of gliomas. Expert Opinion on Biological Therapy, 8(2), 213-220. https://doi.org/10.1517/14712598.8.2.213