Oncolytic measles virus strains in the treatment of gliomas

Cory Allen; Georgia Paraskevakou; Chunsheng Liu; Ianko D. Iankov; Pavlos Msaouel; Paula Zollman; Evanthia Galanis

doi:10.1517/14712598.8.2.213

Oncolytic measles virus strains in the treatment of gliomas

Cory Allen, Georgia Paraskevakou, Chunsheng Liu, Ianko D. Iankov, Pavlos Msaouel, Paula Zollman, Evanthia Galanis

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Background: Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy. Objective: In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas. Methods: Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described. Results/conclusions: Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.

Original language	English (US)
Pages (from-to)	213-220
Number of pages	8
Journal	Expert Opinion on Biological Therapy
Volume	8
Issue number	2
DOIs	https://doi.org/10.1517/14712598.8.2.213
State	Published - Feb 2008

Keywords

Brain tumor
Engineering
Measles virus
Retargeting
Virotherapy

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1517/14712598.8.2.213

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title = "Oncolytic measles virus strains in the treatment of gliomas",

abstract = "Background: Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy. Objective: In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas. Methods: Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described. Results/conclusions: Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.",

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AU - Allen, Cory

AU - Paraskevakou, Georgia

AU - Liu, Chunsheng

AU - Iankov, Ianko D.

AU - Msaouel, Pavlos

AU - Zollman, Paula

AU - Galanis, Evanthia

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AB - Background: Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy. Objective: In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas. Methods: Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described. Results/conclusions: Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.

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Oncolytic measles virus strains in the treatment of gliomas

Abstract

Keywords

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