Oncolytic Measles Virotherapy and Opposition to Measles Vaccination

Stephen J. Russell; Dusica Babovic-Vuksanovic; Alice Bexon; Roberto Cattaneo; David Dingli; Angela Dispenzieri; David R. Deyle; Mark J. Federspiel; Adele Fielding; Eva Galanis; Martha Q. Lacy; Bradley C. Leibovich; Minetta C. Liu; Miguel Muñoz-Alía; Tanner C. Miest; Julian R. Molina; Sabine Mueller; Scott H. Okuno; Nandakumar Packiriswamy; Tobias Peikert; Corey Raffel; Frits Van Rhee; Guy Ungerechts; Paul R. Young; Yumei Zhou; Kah Whye Peng

doi:10.1016/j.mayocp.2019.05.006

Oncolytic Measles Virotherapy and Opposition to Measles Vaccination

Stephen J. Russell, Dusica Babovic-Vuksanovic, Alice Bexon, Roberto Cattaneo, David Dingli, Angela Dispenzieri, David R. Deyle, Mark J. Federspiel, Adele Fielding, Eva Galanis, Martha Q. Lacy, Bradley C. Leibovich, Minetta C. Liu, Miguel Muñoz-Alía, Tanner C. Miest, Julian R. Molina, Sabine Mueller, Scott H. Okuno, Nandakumar Packiriswamy, Tobias PeikertCorey Raffel, Frits Van Rhee, Guy Ungerechts, Paul R. Young, Yumei Zhou, Kah Whye Peng

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument—that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.

Original language	English (US)
Pages (from-to)	1834-1839
Number of pages	6
Journal	Mayo Clinic proceedings
Volume	94
Issue number	9
DOIs	https://doi.org/10.1016/j.mayocp.2019.05.006
State	Published - Sep 2019

ASJC Scopus subject areas

General Medicine

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Russell, S. J., Babovic-Vuksanovic, D., Bexon, A., Cattaneo, R., Dingli, D., Dispenzieri, A., Deyle, D. R., Federspiel, M. J., Fielding, A., Galanis, E., Lacy, M. Q., Leibovich, B. C., Liu, M. C., Muñoz-Alía, M., Miest, T. C., Molina, J. R., Mueller, S., Okuno, S. H., Packiriswamy, N., ... Peng, K. W. (2019). Oncolytic Measles Virotherapy and Opposition to Measles Vaccination. Mayo Clinic proceedings, 94(9), 1834-1839. https://doi.org/10.1016/j.mayocp.2019.05.006

Russell, SJ , Babovic-Vuksanovic, D, Bexon, A, Cattaneo, R , Dingli, D , Dispenzieri, A , Deyle, DR, Federspiel, MJ, Fielding, A, Galanis, E , Lacy, MQ, Leibovich, BC, Liu, MC, Muñoz-Alía, M, Miest, TC, Molina, JR, Mueller, S, Okuno, SH, Packiriswamy, N, Peikert, T, Raffel, C, Van Rhee, F, Ungerechts, G, Young, PR, Zhou, Y & Peng, KW 2019, 'Oncolytic Measles Virotherapy and Opposition to Measles Vaccination', Mayo Clinic proceedings, vol. 94, no. 9, pp. 1834-1839. https://doi.org/10.1016/j.mayocp.2019.05.006

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title = "Oncolytic Measles Virotherapy and Opposition to Measles Vaccination",

abstract = "Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument—that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.",

author = "Russell, {Stephen J.} and Dusica Babovic-Vuksanovic and Alice Bexon and Roberto Cattaneo and David Dingli and Angela Dispenzieri and Deyle, {David R.} and Federspiel, {Mark J.} and Adele Fielding and Eva Galanis and Lacy, {Martha Q.} and Leibovich, {Bradley C.} and Liu, {Minetta C.} and Miguel Mu{\~n}oz-Al{\'i}a and Miest, {Tanner C.} and Molina, {Julian R.} and Sabine Mueller and Okuno, {Scott H.} and Nandakumar Packiriswamy and Tobias Peikert and Corey Raffel and {Van Rhee}, Frits and Guy Ungerechts and Young, {Paul R.} and Yumei Zhou and Peng, {Kah Whye}",

note = "Publisher Copyright: {\textcopyright} 2019 Mayo Foundation for Medical Education and Research",

year = "2019",

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doi = "10.1016/j.mayocp.2019.05.006",

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AU - Babovic-Vuksanovic, Dusica

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AU - Cattaneo, Roberto

AU - Dingli, David

AU - Dispenzieri, Angela

AU - Deyle, David R.

AU - Federspiel, Mark J.

AU - Fielding, Adele

AU - Galanis, Eva

AU - Lacy, Martha Q.

AU - Leibovich, Bradley C.

AU - Liu, Minetta C.

AU - Muñoz-Alía, Miguel

AU - Miest, Tanner C.

AU - Molina, Julian R.

AU - Mueller, Sabine

AU - Okuno, Scott H.

AU - Packiriswamy, Nandakumar

AU - Peikert, Tobias

AU - Raffel, Corey

AU - Van Rhee, Frits

AU - Ungerechts, Guy

AU - Young, Paul R.

AU - Zhou, Yumei

AU - Peng, Kah Whye

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N2 - Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument—that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.

AB - Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument—that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.

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Oncolytic Measles Virotherapy and Opposition to Measles Vaccination

Abstract

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