@article{f338553c03d342c9a7acf368ca228fd2,
title = "Oncolytic Activity of Targeted Picornaviruses Formulated as Synthetic Infectious RNA",
abstract = "Elsedawy and colleagues determined the optimal configuration for microRNA detargeting of CVA21 involved in replacing the spacer region downstream of the IRES with the microRNA response element. Treatment with infectious RNA encoding this configuration resulted in tumor regression, ameliorated toxicity, and significantly enhanced survival, paving the way for targeted-RNA-based oncolytic CVA21 virotherapy.",
keywords = "Cancer, Coxsackievirus A21, Infectious Nucleic Acid, MicroRNA, Oncolytic, Picornavirus, RNA, Targeting, Virotherapy, Virus",
author = "Elsedawy, {Noura B.} and Nace, {Rebecca A.} and Russell, {Stephen J.} and Schulze, {Autumn J.}",
note = "Funding Information: We thank E. Rieder and E. Wimmer (State University of New York-Stony Brook) for the initial construction of an infectious CVA21 clone. Additionally, we thank A. Dufresne and M. Gromeier (Duke University) for kindly providing the CVA21 clone. We thank Dr. Jim Maher III (Mayo Clinic) for communications regarding RNA structural analysis. We thank the Mayo Clinic Center for Clinical and Translational Sciences biostatisticians for their help with statistical analyses. We also sincerely and respectfully acknowledge the revolutionary contribution to medical research made possible by Henrietta Lacks and HeLa cells. The graphical abstract was created with BioRender.com . This work was funded by Al and Mary Agnes McQuinn and Mayo Clinic , United States. Funding Information: We thank E. Rieder and E. Wimmer (State University of New York-Stony Brook) for the initial construction of an infectious CVA21 clone. Additionally, we thank A. Dufresne and M. Gromeier (Duke University) for kindly providing the CVA21 clone. We thank Dr. Jim Maher III (Mayo Clinic) for communications regarding RNA structural analysis. We thank the Mayo Clinic Center for Clinical and Translational Sciences biostatisticians for their help with statistical analyses. We also sincerely and respectfully acknowledge the revolutionary contribution to medical research made possible by Henrietta Lacks and HeLa cells. The graphical abstract was created with BioRender.com. This work was funded by Al and Mary Agnes McQuinn and Mayo Clinic, United States. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = jun,
day = "26",
doi = "10.1016/j.omto.2020.05.003",
language = "English (US)",
volume = "17",
pages = "484--495",
journal = "Molecular Therapy - Oncolytics",
issn = "2372-7705",
publisher = "Nature Publishing Group",
}