Oncolytic Activity of Targeted Picornaviruses Formulated as Synthetic Infectious RNA

Noura B. Elsedawy, Rebecca A. Nace, Stephen J. Russell, Autumn J. Schulze

Research output: Contribution to journalArticle

Abstract

Elsedawy and colleagues determined the optimal configuration for microRNA detargeting of CVA21 involved in replacing the spacer region downstream of the IRES with the microRNA response element. Treatment with infectious RNA encoding this configuration resulted in tumor regression, ameliorated toxicity, and significantly enhanced survival, paving the way for targeted-RNA-based oncolytic CVA21 virotherapy.

Original languageEnglish (US)
Pages (from-to)484-495
Number of pages12
JournalMolecular Therapy - Oncolytics
Volume17
DOIs
StatePublished - Jun 26 2020

Keywords

  • Cancer
  • Coxsackievirus A21
  • Infectious Nucleic Acid
  • MicroRNA
  • Oncolytic
  • Picornavirus
  • RNA
  • Targeting
  • Virotherapy
  • Virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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