Oncological outcome of peripartum colorectal carcinoma—a single-center experience

Fabian Grass, Blake A. Spindler, Nimesh D. Naik, Cornelius A. Thiels, Eric Dozois, David Larson, Kellie L. Mathis

Research output: Contribution to journalArticle

Abstract

Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC). Methods: Retrospective cohort study of all consecutive women of childbearing age (18–45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Overall survival (OS) was compared between the two groups through Kaplan-Meier estimates. Results: Out of 555 consecutive women with a mean age of 37.8 + 6 years, 31 (5.6%) were diagnosed with CRC in the peripartum period. Of these, all patients were symptomatic during pregnancy due to bleeding, abdominal pain, or constipation; however, only 11 CRC (35.5%) were diagnosed during pregnancy, 1 (3.2%) during C section, and the remaining (61.3%) postpartum. TNM stage at presentation was I in 6 patients (19.4%), II in 4 patients (13.9%), III in 8 patients (25.8%), and IV in 13 patients (41.9%). Surgical resection was performed in 23 patients (74.2%): 2 while pregnant, 2 at the time of C section, and the remainder postpartum. Across all stages, OS was 95% at 1 year and 62% at 5 years and did not differ between the two comparative groups (p = 0.16). Conclusions: A suspicious attitude towards cancer-related symptoms during pregnancy is crucial to prevent delayed evaluation for CRC.

Original languageEnglish (US)
JournalInternational Journal of Colorectal Disease
DOIs
StatePublished - Jan 1 2019

Fingerprint

Peripartum Period
Colorectal Neoplasms
Pregnancy
Postpartum Period
Survival
Kaplan-Meier Estimate
Constipation
Disease Management
Abdominal Pain
Adenocarcinoma
Cohort Studies
Retrospective Studies
Hemorrhage

Keywords

  • Colorectal carcinoma
  • Outcome
  • Pregnancy
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Oncological outcome of peripartum colorectal carcinoma—a single-center experience. / Grass, Fabian; Spindler, Blake A.; Naik, Nimesh D.; Thiels, Cornelius A.; Dozois, Eric; Larson, David; Mathis, Kellie L.

In: International Journal of Colorectal Disease, 01.01.2019.

Research output: Contribution to journalArticle

Grass, Fabian ; Spindler, Blake A. ; Naik, Nimesh D. ; Thiels, Cornelius A. ; Dozois, Eric ; Larson, David ; Mathis, Kellie L. / Oncological outcome of peripartum colorectal carcinoma—a single-center experience. In: International Journal of Colorectal Disease. 2019.
@article{9be8186945ef4ee782dcc18956d189b8,
title = "Oncological outcome of peripartum colorectal carcinoma—a single-center experience",
abstract = "Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC). Methods: Retrospective cohort study of all consecutive women of childbearing age (18–45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Overall survival (OS) was compared between the two groups through Kaplan-Meier estimates. Results: Out of 555 consecutive women with a mean age of 37.8 + 6 years, 31 (5.6{\%}) were diagnosed with CRC in the peripartum period. Of these, all patients were symptomatic during pregnancy due to bleeding, abdominal pain, or constipation; however, only 11 CRC (35.5{\%}) were diagnosed during pregnancy, 1 (3.2{\%}) during C section, and the remaining (61.3{\%}) postpartum. TNM stage at presentation was I in 6 patients (19.4{\%}), II in 4 patients (13.9{\%}), III in 8 patients (25.8{\%}), and IV in 13 patients (41.9{\%}). Surgical resection was performed in 23 patients (74.2{\%}): 2 while pregnant, 2 at the time of C section, and the remainder postpartum. Across all stages, OS was 95{\%} at 1 year and 62{\%} at 5 years and did not differ between the two comparative groups (p = 0.16). Conclusions: A suspicious attitude towards cancer-related symptoms during pregnancy is crucial to prevent delayed evaluation for CRC.",
keywords = "Colorectal carcinoma, Outcome, Pregnancy, Survival",
author = "Fabian Grass and Spindler, {Blake A.} and Naik, {Nimesh D.} and Thiels, {Cornelius A.} and Eric Dozois and David Larson and Mathis, {Kellie L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00384-019-03278-2",
language = "English (US)",
journal = "International Journal of Colorectal Disease",
issn = "0179-1958",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Oncological outcome of peripartum colorectal carcinoma—a single-center experience

AU - Grass, Fabian

AU - Spindler, Blake A.

AU - Naik, Nimesh D.

AU - Thiels, Cornelius A.

AU - Dozois, Eric

AU - Larson, David

AU - Mathis, Kellie L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC). Methods: Retrospective cohort study of all consecutive women of childbearing age (18–45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Overall survival (OS) was compared between the two groups through Kaplan-Meier estimates. Results: Out of 555 consecutive women with a mean age of 37.8 + 6 years, 31 (5.6%) were diagnosed with CRC in the peripartum period. Of these, all patients were symptomatic during pregnancy due to bleeding, abdominal pain, or constipation; however, only 11 CRC (35.5%) were diagnosed during pregnancy, 1 (3.2%) during C section, and the remaining (61.3%) postpartum. TNM stage at presentation was I in 6 patients (19.4%), II in 4 patients (13.9%), III in 8 patients (25.8%), and IV in 13 patients (41.9%). Surgical resection was performed in 23 patients (74.2%): 2 while pregnant, 2 at the time of C section, and the remainder postpartum. Across all stages, OS was 95% at 1 year and 62% at 5 years and did not differ between the two comparative groups (p = 0.16). Conclusions: A suspicious attitude towards cancer-related symptoms during pregnancy is crucial to prevent delayed evaluation for CRC.

AB - Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC). Methods: Retrospective cohort study of all consecutive women of childbearing age (18–45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Overall survival (OS) was compared between the two groups through Kaplan-Meier estimates. Results: Out of 555 consecutive women with a mean age of 37.8 + 6 years, 31 (5.6%) were diagnosed with CRC in the peripartum period. Of these, all patients were symptomatic during pregnancy due to bleeding, abdominal pain, or constipation; however, only 11 CRC (35.5%) were diagnosed during pregnancy, 1 (3.2%) during C section, and the remaining (61.3%) postpartum. TNM stage at presentation was I in 6 patients (19.4%), II in 4 patients (13.9%), III in 8 patients (25.8%), and IV in 13 patients (41.9%). Surgical resection was performed in 23 patients (74.2%): 2 while pregnant, 2 at the time of C section, and the remainder postpartum. Across all stages, OS was 95% at 1 year and 62% at 5 years and did not differ between the two comparative groups (p = 0.16). Conclusions: A suspicious attitude towards cancer-related symptoms during pregnancy is crucial to prevent delayed evaluation for CRC.

KW - Colorectal carcinoma

KW - Outcome

KW - Pregnancy

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85064076345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064076345&partnerID=8YFLogxK

U2 - 10.1007/s00384-019-03278-2

DO - 10.1007/s00384-019-03278-2

M3 - Article

C2 - 30915541

AN - SCOPUS:85064076345

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

SN - 0179-1958

ER -