TY - JOUR
T1 - Oncogenic transcription factors
T2 - Cornerstones of inflammation-linked pancreatic carcinogenesis
AU - Baumgart, Sandra
AU - Ellenrieder, Volker
AU - Fernandez-Zapico, Martin E.
PY - 2013/2
Y1 - 2013/2
N2 - Transcription factors are proteins that regulate gene expression by modulating the synthesis of messenger RNA. Since this process is often one dominant control point in the production of many proteins, transcription factors represent the key regulators of numerous cellular functions, including proliferation, differentiation and apoptosis. Pancreatic cancer progression is characterised by activation of inflammatory signalling pathways converging on a limited set of transcription factors that fine-tune gene expression patterns contributing to the growth and maintenance of these tumours. Thus strategies targeting these transcriptional networks activated in pancreatic cancer cells could block the effects of upstream inflammatory responses participating in pancreatic tumorigenesis. The authors review this field of research and summarise current strategies for targeting oncogenic transcription factors and their activating signalling networks in the treatment of pancreatic cancer.
AB - Transcription factors are proteins that regulate gene expression by modulating the synthesis of messenger RNA. Since this process is often one dominant control point in the production of many proteins, transcription factors represent the key regulators of numerous cellular functions, including proliferation, differentiation and apoptosis. Pancreatic cancer progression is characterised by activation of inflammatory signalling pathways converging on a limited set of transcription factors that fine-tune gene expression patterns contributing to the growth and maintenance of these tumours. Thus strategies targeting these transcriptional networks activated in pancreatic cancer cells could block the effects of upstream inflammatory responses participating in pancreatic tumorigenesis. The authors review this field of research and summarise current strategies for targeting oncogenic transcription factors and their activating signalling networks in the treatment of pancreatic cancer.
UR - http://www.scopus.com/inward/record.url?scp=84872065981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872065981&partnerID=8YFLogxK
U2 - 10.1136/gutjnl-2011-301008
DO - 10.1136/gutjnl-2011-301008
M3 - Review article
C2 - 21997559
AN - SCOPUS:84872065981
SN - 0017-5749
VL - 62
SP - 310
EP - 316
JO - Gut
JF - Gut
IS - 2
ER -