TY - JOUR
T1 - Oncogenic protein kinase Cι signaling mechanisms in lung cancer
T2 - Implications for improved therapeutic strategies
AU - Yin, Ning
AU - Liu, Yi
AU - Murray, Nicole R.
AU - Fields, Alan P.
N1 - Publisher Copyright:
© 2019
PY - 2020/1
Y1 - 2020/1
N2 - Protein Kinase Cι (PKCι) is a major oncogene involved in the initiation, maintenance and progression of numerous forms of human cancer. In the lung, PKCι is necessary for the maintenance of the transformed phenotype of the two major forms of non-small cell lung cancer (NSCLC), lung adenocarcinoma (LADC) and lung squamous cell carcinoma (LSCC). In addition, PKCι is necessary for both LADC and LSCC tumorigenesis by establishing and maintaining a highly aggressive stem-like, tumor-initiating cell phenotype. Interestingly however, while PKCι signaling in these two major lung cancer subtypes shares some common elements, it also drives distinct, sub-type specific pathways. Furthermore, recent analysis has revealed both PKCι-dependent and PKCι-independent pathways to LADC development. Herein, we discussion our current knowledge of oncogenic PKCι signaling in LADC and LSCC, and discuss these findings in the context of how they may inform strategies for improved therapeutic intervention in these deadly diseases.
AB - Protein Kinase Cι (PKCι) is a major oncogene involved in the initiation, maintenance and progression of numerous forms of human cancer. In the lung, PKCι is necessary for the maintenance of the transformed phenotype of the two major forms of non-small cell lung cancer (NSCLC), lung adenocarcinoma (LADC) and lung squamous cell carcinoma (LSCC). In addition, PKCι is necessary for both LADC and LSCC tumorigenesis by establishing and maintaining a highly aggressive stem-like, tumor-initiating cell phenotype. Interestingly however, while PKCι signaling in these two major lung cancer subtypes shares some common elements, it also drives distinct, sub-type specific pathways. Furthermore, recent analysis has revealed both PKCι-dependent and PKCι-independent pathways to LADC development. Herein, we discussion our current knowledge of oncogenic PKCι signaling in LADC and LSCC, and discuss these findings in the context of how they may inform strategies for improved therapeutic intervention in these deadly diseases.
KW - Genetically-engineered mouse models
KW - Lung adenocarcinoma
KW - Lung squamous cell carcinoma
KW - Oncogenic signaling pathways
KW - Protein kinase Cι
UR - http://www.scopus.com/inward/record.url?scp=85073557108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073557108&partnerID=8YFLogxK
U2 - 10.1016/j.jbior.2019.100656
DO - 10.1016/j.jbior.2019.100656
M3 - Article
C2 - 31623973
AN - SCOPUS:85073557108
SN - 2212-4926
VL - 75
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
M1 - 100656
ER -