Oncogenic osteomalacia: Localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy

Stephen F. Hodgson, Bart Clarke, Peter Tebben, Brian P. Mullan, William P. Cooney, Thomas C. Shives

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31 Citations (Scopus)

Abstract

Objective: To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases. Methods: Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed. Results: Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure. Conclusion: We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalEndocrine Practice
Volume12
Issue number1
StatePublished - Jan 2006

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Radionuclide Imaging
Neoplasms
Familial Hypophosphatemia
Hypophosphatemia
Osteomalacia
Phosphorus
Oncogenic osteomalacia
Costs and Cost Analysis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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Oncogenic osteomalacia : Localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy. / Hodgson, Stephen F.; Clarke, Bart; Tebben, Peter; Mullan, Brian P.; Cooney, William P.; Shives, Thomas C.

In: Endocrine Practice, Vol. 12, No. 1, 01.2006, p. 35-42.

Research output: Contribution to journalArticle

Hodgson, Stephen F. ; Clarke, Bart ; Tebben, Peter ; Mullan, Brian P. ; Cooney, William P. ; Shives, Thomas C. / Oncogenic osteomalacia : Localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy. In: Endocrine Practice. 2006 ; Vol. 12, No. 1. pp. 35-42.
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