Oncogenic K-Ras requires activation for enhanced activity

H. Huang, J. Daniluk, Y. Liu, J. Chu, Z. Li, B. Ji, C. D. Logsdon

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Oncogenic Ras mutations are widely considered to be locked in a permanent 'On' state and 'constitutively active'. Yet, many healthy people have cells possessing mutant Ras without apparent harm, and in animal models mutant Ras causes transformation only after upregulation of Ras activity. Here, we demonstrate that oncogenic K-Ras is not constitutively active but can be readily activated by upstream stimulants to lead to prolonged strong Ras activity. These data indicate that in addition to targeting K-Ras downstream effectors, interventions to reduce K-Ras activation may have important cancer-preventive value, especially in patients with oncogenic Ras mutations. As other small G proteins are regulated in a similar manner, this concept is likely to apply broadly to the entire Ras family of molecules.

Original languageEnglish (US)
Pages (from-to)532-535
Number of pages4
JournalOncogene
Volume33
Issue number4
DOIs
StatePublished - Jan 23 2014

Keywords

  • Cancer
  • Ras-GTP

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Huang, H., Daniluk, J., Liu, Y., Chu, J., Li, Z., Ji, B., & Logsdon, C. D. (2014). Oncogenic K-Ras requires activation for enhanced activity. Oncogene, 33(4), 532-535. https://doi.org/10.1038/onc.2012.619