TY - JOUR
T1 - On the role of urocortin 1 in the non-preganglionic Edinger-Westphal nucleus in stress adaptation
AU - Kozicz, Tamás
N1 - Funding Information:
This work was supported by Nederland Organization for Scientific Research, NWO (#864.05.008).
PY - 2007
Y1 - 2007
N2 - The discovery of novel members of the CRF neuropeptide family, urocortin 1 (Ucn1), urocortin 2 and 3 has provided important insights into stress adaptation pathways, and predicted that stress adaptation involves more systems than the HPA-axis alone. This mini-review aims to summarize our recent data and research by others indicating that an important role is played by Ucn1 in the non-preganglionic Edinger-Westphal nucleus (npEW). These results point to an intriguing possibility that CRF/Ucn1 neuronal circuits comprise two separate, but functionally interrelated entities, which are coordinately regulated by acute stressors, but are inversely coupled during chronic stress. Such collaboration between the two systems would implicate a very important role of Ucn1 in adaptation to stress, and, as a consequence, in stress-related disorders like anxiety, major depression and use of drugs of abuse.
AB - The discovery of novel members of the CRF neuropeptide family, urocortin 1 (Ucn1), urocortin 2 and 3 has provided important insights into stress adaptation pathways, and predicted that stress adaptation involves more systems than the HPA-axis alone. This mini-review aims to summarize our recent data and research by others indicating that an important role is played by Ucn1 in the non-preganglionic Edinger-Westphal nucleus (npEW). These results point to an intriguing possibility that CRF/Ucn1 neuronal circuits comprise two separate, but functionally interrelated entities, which are coordinately regulated by acute stressors, but are inversely coupled during chronic stress. Such collaboration between the two systems would implicate a very important role of Ucn1 in adaptation to stress, and, as a consequence, in stress-related disorders like anxiety, major depression and use of drugs of abuse.
KW - Non-preganglionic Edinger-Westphal nucleus
KW - Stress adaptation
KW - Urocortin 1
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U2 - 10.1016/j.ygcen.2007.04.005
DO - 10.1016/j.ygcen.2007.04.005
M3 - Short survey
C2 - 17517410
AN - SCOPUS:34548683270
SN - 0016-6480
VL - 153
SP - 235
EP - 240
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 1-3
ER -