On the aging of organisms and their cells

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

An explanation of organismic ageing based on a limited division capacity of dividing cells is difficult to reconcile with much of the available data. The physiology of cells in ageing organisms tends, on the contrary, to suggest that organisms age as a result of degeneration in their non-dividing cell populations. Senescence in these non-mitotic cells resembles the ageing of the non-dividing fraction of cell cultures clonally senescing, or maintained in long-term quiescence invitro. As cultures of diploid human fibroblasts senesce there is an accumulation of non-dividing cells. Alterations in these post-mitotic cells can explain the senescent properties of late passage cultures. It is proposed that during the invitro senescence of fibroblast cultures, cell ageing results from, as opposed to causes, the absence of mitosis. Cell ageing may primarily result from changes in the chromatin induced by the non-mitotic state.

Original languageEnglish (US)
Pages (from-to)53-66
Number of pages14
JournalMedical Hypotheses
Volume5
Issue number1
DOIs
StatePublished - Jan 1979

Keywords

  • Ageing
  • cell cycle
  • chromatin

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'On the aging of organisms and their cells'. Together they form a unique fingerprint.

  • Cite this