On solid-phase antibody assays

Octavio E. Pajaro, James F. George

Research output: Contribution to journalEditorial

8 Scopus citations

Abstract

There is considerable evidence that pre-operative and post-operative anti-human leukocyte antigen (anti-HLA) antibodies are deleterious in thoracic transplantation. While debate continues in heart and lung transplantation on the role of and the diagnosis and treatment of antibody-mediated rejection (AMR), central to the discussion is our ability to detect anti-HLA antibodies. This perspective outlines the concerns elicited by new technology for detection of anti-HLA antibodies using solid-phase assays, and highlights the need for functional assays to further understand the clinical significance of these antibodies.

Original languageEnglish (US)
Pages (from-to)1207-1209
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume29
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • anti-HLA antibody
  • antibody-mediated rejection
  • panel reactive antibodies
  • solid-phase assays
  • virtual crossmatch

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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