TY - JOUR
T1 - Omentum patch substitute for facilitating endoscopic repair of GI perforations
T2 - An early laparoscopic pilot study with a foam matrix plug (with video)
AU - Bonin, Eduardo A.
AU - Bingener, Juliane
AU - Rajan, Elizabeth
AU - Knipschield, Mary
AU - Gostout, Christopher J.
PY - 2013/1
Y1 - 2013/1
N2 - Background: Endoscopic perforations are surgically repaired by using an omentum patch. Omentum substitutes may have broader applications particularly in certain sites (eg, esophagus). Objective: Evaluate a self-expandable foam matrix plug as a synthetic omentum substitute for repairing iatrogenic gastric perforations in a 4-week survival pig model. Design: Experimental pilot study. Setting: Laboratory. Intervention: A laparoscopic plug repair of a 1-cm, full-thickness, gastric perforation was carried out by using either a polyurethane foam matrix plug (FMP, 8 animals) or an omentum plug (OP, 6 animals, control group). Main Outcome Measurements: Follow-up endoscopy was carried out at 1 and 4 weeks. At necropsy, the perforation site was evaluated for adhesions and histology by using hematoxylin and eosin analysis. A portion of the implant was sent for bacterial and fungal culture. Results: All procedures were technically simple and successful. Thirteen animals thrived well for 4 weeks. One animal from the FMP group died 3 days postoperatively from diffuse peritonitis because of a misplaced plug. All remaining FMPs were intact at 4 weeks and colonized with mixed bacteria, except one animal presenting with FMP migration after 1 week. Histologically, the FMP group had more prominent inflammation and suppuration as compared with the OP group, all limited to its adjacent tissue. Limitations: Animal study. Conclusion: The FMP offered a technically simple and feasible option for repairing iatrogenic gastric perforations. With effective sealing, the clinical outcome is similar to that of an omentum patch repair. Migration and inadequate sealing is a concern, which can lead to peritonitis and sepsis. Further development is needed to improve FMP performance.
AB - Background: Endoscopic perforations are surgically repaired by using an omentum patch. Omentum substitutes may have broader applications particularly in certain sites (eg, esophagus). Objective: Evaluate a self-expandable foam matrix plug as a synthetic omentum substitute for repairing iatrogenic gastric perforations in a 4-week survival pig model. Design: Experimental pilot study. Setting: Laboratory. Intervention: A laparoscopic plug repair of a 1-cm, full-thickness, gastric perforation was carried out by using either a polyurethane foam matrix plug (FMP, 8 animals) or an omentum plug (OP, 6 animals, control group). Main Outcome Measurements: Follow-up endoscopy was carried out at 1 and 4 weeks. At necropsy, the perforation site was evaluated for adhesions and histology by using hematoxylin and eosin analysis. A portion of the implant was sent for bacterial and fungal culture. Results: All procedures were technically simple and successful. Thirteen animals thrived well for 4 weeks. One animal from the FMP group died 3 days postoperatively from diffuse peritonitis because of a misplaced plug. All remaining FMPs were intact at 4 weeks and colonized with mixed bacteria, except one animal presenting with FMP migration after 1 week. Histologically, the FMP group had more prominent inflammation and suppuration as compared with the OP group, all limited to its adjacent tissue. Limitations: Animal study. Conclusion: The FMP offered a technically simple and feasible option for repairing iatrogenic gastric perforations. With effective sealing, the clinical outcome is similar to that of an omentum patch repair. Migration and inadequate sealing is a concern, which can lead to peritonitis and sepsis. Further development is needed to improve FMP performance.
KW - CG
KW - FMP
KW - OP
KW - OPR
KW - PG
KW - control (omentum repair) group
KW - foam matrix plug
KW - omentum patch repair
KW - omentum plug
KW - plug (foam matrix) group
UR - http://www.scopus.com/inward/record.url?scp=84871329268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871329268&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2012.09.020
DO - 10.1016/j.gie.2012.09.020
M3 - Article
C2 - 23261102
AN - SCOPUS:84871329268
SN - 0016-5107
VL - 77
SP - 123
EP - 130
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 1
ER -