Omentum patch substitute for facilitating endoscopic repair of GI perforations: An early laparoscopic pilot study with a foam matrix plug (with video)

Eduardo A. Bonin, Juliane Bingener, Elizabeth Rajan, Mary Knipschield, Christopher J. Gostout

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Endoscopic perforations are surgically repaired by using an omentum patch. Omentum substitutes may have broader applications particularly in certain sites (eg, esophagus). Objective: Evaluate a self-expandable foam matrix plug as a synthetic omentum substitute for repairing iatrogenic gastric perforations in a 4-week survival pig model. Design: Experimental pilot study. Setting: Laboratory. Intervention: A laparoscopic plug repair of a 1-cm, full-thickness, gastric perforation was carried out by using either a polyurethane foam matrix plug (FMP, 8 animals) or an omentum plug (OP, 6 animals, control group). Main Outcome Measurements: Follow-up endoscopy was carried out at 1 and 4 weeks. At necropsy, the perforation site was evaluated for adhesions and histology by using hematoxylin and eosin analysis. A portion of the implant was sent for bacterial and fungal culture. Results: All procedures were technically simple and successful. Thirteen animals thrived well for 4 weeks. One animal from the FMP group died 3 days postoperatively from diffuse peritonitis because of a misplaced plug. All remaining FMPs were intact at 4 weeks and colonized with mixed bacteria, except one animal presenting with FMP migration after 1 week. Histologically, the FMP group had more prominent inflammation and suppuration as compared with the OP group, all limited to its adjacent tissue. Limitations: Animal study. Conclusion: The FMP offered a technically simple and feasible option for repairing iatrogenic gastric perforations. With effective sealing, the clinical outcome is similar to that of an omentum patch repair. Migration and inadequate sealing is a concern, which can lead to peritonitis and sepsis. Further development is needed to improve FMP performance.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalGastrointestinal Endoscopy
Volume77
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Omentum
Stomach
Peritonitis
Suppuration
Hematoxylin
Eosine Yellowish-(YS)
N-formylmethionylphenylalanine
Esophagus
Endoscopy
Sepsis
Histology
Research Design
Swine
Inflammation
Bacteria
Control Groups

Keywords

  • CG
  • control (omentum repair) group
  • FMP
  • foam matrix plug
  • omentum patch repair
  • omentum plug
  • OP
  • OPR
  • PG
  • plug (foam matrix) group

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Omentum patch substitute for facilitating endoscopic repair of GI perforations : An early laparoscopic pilot study with a foam matrix plug (with video). / Bonin, Eduardo A.; Bingener, Juliane; Rajan, Elizabeth; Knipschield, Mary; Gostout, Christopher J.

In: Gastrointestinal Endoscopy, Vol. 77, No. 1, 01.2013, p. 123-130.

Research output: Contribution to journalArticle

Bonin, Eduardo A. ; Bingener, Juliane ; Rajan, Elizabeth ; Knipschield, Mary ; Gostout, Christopher J. / Omentum patch substitute for facilitating endoscopic repair of GI perforations : An early laparoscopic pilot study with a foam matrix plug (with video). In: Gastrointestinal Endoscopy. 2013 ; Vol. 77, No. 1. pp. 123-130.
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