Olfactory Dysfunction

Andreas Puschmann, Zbigniew K Wszolek

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson's disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of -olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance reflects Lewy pathology more closely than it reflects striatonigral dopamine deficiency.

Original languageEnglish (US)
Pages (from-to)335-348
Number of pages14
JournalMilestones in Drug Therapy
Volume24
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Parkinsonian Disorders
Parkinson Disease
Dopamine
Anatomy
Pathology

Keywords

  • Hyposmia
  • Olfaction
  • Olfactory nerve
  • Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Drug Discovery

Cite this

Olfactory Dysfunction. / Puschmann, Andreas; Wszolek, Zbigniew K.

In: Milestones in Drug Therapy, Vol. 24, 2013, p. 335-348.

Research output: Contribution to journalArticle

Puschmann, Andreas ; Wszolek, Zbigniew K. / Olfactory Dysfunction. In: Milestones in Drug Therapy. 2013 ; Vol. 24. pp. 335-348.
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